Institute of Myology, Neuromuscular Investigation Center, NMR Laboratory, Paris, France.
CEA, DRF, IBFJ, MIRCen, NMR Laboratory, Paris, France.
Sci Rep. 2019 May 2;9(1):6852. doi: 10.1038/s41598-019-43398-x.
We investigated the response of skeletal muscle global T1 under different physiological and pathological conditions using an inversion-recovery radial T1 mapping sequence. Thirty five healthy volunteers, seven patients with Becker muscular dystrophy (BMD) and seven patients with sporadic inclusion body myositis (IBM) were investigated in order to evaluate the effects of gender, age, muscle group, exercise and pathological processes on global T1 values. In addition, the intramuscular fat content was measured using 3-point Dixon and the global T2 and water T2 (T2) were determined with a multi-spin-echo sequence. In the muscles of healthy volunteers, there was no impact of age on global T1. However, we measured a significant effect of sex and muscle group. After exercise, a significant 7.7% increase of global T1 was measured in the recruited muscles, and global T1 variations were highly correlated to T2 variations (R = 0.91). In pathologies, global T1 values were reduced in fat infiltrated muscles. When fat fraction was taken into account, global T1 values were higher in IBM patients compared to BMD. Global T1 variations are a sensitive indicator of tissue changes in skeletal muscle related to several physiological and pathological events.
我们使用反转恢复放射状 T1 映射序列研究了不同生理和病理条件下骨骼肌的整体 T1 响应。为了评估性别、年龄、肌肉群、运动和病理过程对整体 T1 值的影响，我们调查了 35 名健康志愿者、7 名贝克型肌营养不良症（BMD）患者和 7 名散发性包涵体肌炎（IBM）患者。此外，使用 3 点 Dixon 测量了肌肉内脂肪含量，并使用多自旋回波序列确定了整体 T2 和水 T2（T2）。在健康志愿者的肌肉中，年龄对整体 T1 没有影响。然而，我们测量到性别和肌肉群有显著影响。运动后，募集肌肉的整体 T1 增加了 7.7%，整体 T1 的变化与 T2 的变化高度相关（R=0.91）。在病变中，脂肪浸润的肌肉中整体 T1 值降低。当考虑脂肪分数时，与 BMD 相比，IBM 患者的整体 T1 值更高。整体 T1 变化是与多种生理和病理事件相关的骨骼肌组织变化的敏感指标。
