RNA 修饰调控癌症中的细胞命运。
RNA modifications regulating cell fate in cancer.
机构信息
Department of Genetics, University of Cambridge, Cambridge, UK.
German Cancer Center (DKFZ), Im Neuenheimer Feld, Heidelberg, Germany.
出版信息
Nat Cell Biol. 2019 May;21(5):552-559. doi: 10.1038/s41556-019-0319-0. Epub 2019 May 2.
The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributor to cancer. By modulating cell survival, differentiation, migration and drug resistance, RNA modifications add another regulatory layer of complexity to most aspects of tumourigenesis.
RNA 化学修饰的沉积是发育过程中时空基因表达程序的关键调节剂。因此，RNA 修饰模式的改变与发育疾病广泛相关。最近，RNA 修饰途径的失调也被认为是癌症的一个促成因素。通过调节细胞存活、分化、迁移和耐药性，RNA 修饰为肿瘤发生的大多数方面增加了另一个复杂的调控层。
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