Niukian K, Schwartz J, Shklar G
Nutr Cancer. 1987;9(2-3):171-6. doi: 10.1080/01635588709513924.
One-hundred male, young-adult Syrian hamsters (Mesocricetus auratus) were divided into five equal groups of 20 animals each. Groups 1, 2, and 3 were painted three times a week in the left buccal pouches with a 0.5% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in mineral oil. Group 1 animals also received a 20% onion extract in their drinking water and were also painted in left buccal pouches three times a week with a 50% onion extract in mineral oil. Group 2 animals received the onion extract in their drinking water, but they received only mineral oil in buccal pouches as a control for the painting with onion extract in mineral oil. Group 3 animals received DMBA but no onion extract. Group 4 animals received onion extract but no DMBA, and Group 5 animals were left untreated. Onion extract was found to significantly delay tumor formation in Groups 1 and 2 compared with Group 3 DMBA controls.
100只雄性叙利亚青年仓鼠（金仓鼠）被平均分为5组，每组20只。第1、2和3组每周3次在左颊囊涂抹溶于矿物油的0.5% 7,12 - 二甲基苯并[a]蒽（DMBA）溶液。第1组动物的饮用水中还添加了20%的洋葱提取物，并且每周3次在左颊囊涂抹溶于矿物油的50%洋葱提取物。第2组动物的饮用水中添加了洋葱提取物，但它们在颊囊只接受矿物油涂抹，作为用溶于矿物油的洋葱提取物涂抹的对照。第3组动物接受DMBA但不接受洋葱提取物。第4组动物接受洋葱提取物但不接受DMBA，第5组动物不做处理。结果发现，与第3组DMBA对照组相比，第1组和第2组中的洋葱提取物显著延迟了肿瘤形成。
