与促黄体激素释放激素拮抗剂相比，具有抑制素样活性的合成肽优先抑制促卵泡激素分泌。
Synthetic peptide with inhibin-like activity preferentially inhibits follitropin secretion in comparison with lutropin-releasing hormone antagonists.
作者信息
Sairam M R, Ramasharma K, Li C H
出版信息
Proc Natl Acad Sci U S A. 1987 Apr;84(7):2043-6. doi: 10.1073/pnas.84.7.2043.
Abstract
Biological activity of a synthetic peptide with inhibin-like activity under in vitro and in vivo conditions was compared with three highly potent synthetic lutropin-releasing hormone antagonists. Unlike the synthetic lutropin-releasing hormone antagonists, which effectively inhibited both lutropin and follitropin secretion from the pituitary, the inhibin-like peptide showed a preferential effect by inhibiting follitropin release both in vitro and in vivo. Thus, small peptides such as inhibin-like peptide with a sequence unrelated to lutropin-releasing hormone may provide a basis for design of selective inhibitors of gonadotropin release.
摘要
将一种具有抑制素样活性的合成肽在体外和体内条件下的生物活性与三种高效合成促黄体生成素释放激素拮抗剂进行了比较。与能有效抑制垂体促黄体生成素和促卵泡生成素分泌的合成促黄体生成素释放激素拮抗剂不同，这种抑制素样肽在体外和体内均通过抑制促卵泡生成素释放表现出优先效应。因此，诸如与促黄体生成素释放激素序列无关的抑制素样肽这类小肽，可能为设计促性腺激素释放的选择性抑制剂提供基础。
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