Winsel K, Grollmuss H, Unger U, Renner H
Pharmazie. 1986 Nov;41(11):796-9.
The effect of ambroxol and bromhexine on the yeast cell wall- and arachidonic acid (AA)-induced luminol-respectively lucigenin-dependent chemiluminescence (CL) of alveolar macrophages (AM) of patients with lung diseases has been investigated. Both drugs cause a suppression of the induced CL. These results suggest that ambroxol and bromhexine reduce the generation of reactive oxygen metabolites (ROM) by AM. The mechanism of action is thought to involve the activation of the acyl-CoA: lysophosphatide acyltransferase. The increase of this enzyme activity lowers probably the intracellular concentration of free AA and consequently also the production of ROM. The investigations show a new possibility for the influence of biosynthesis of ROM and likely of eicosanoids, which play an important role as pathogenetic mediators in different lung diseases.
已研究氨溴索和溴己新对肺部疾病患者肺泡巨噬细胞（AM）的酵母细胞壁和花生四烯酸（AA）诱导的鲁米诺分别依赖光泽精的化学发光（CL）的影响。两种药物均能抑制诱导的CL。这些结果表明，氨溴索和溴己新可减少AM产生的活性氧代谢产物（ROM）。其作用机制被认为涉及酰基辅酶A：溶血磷脂酰转移酶的激活。该酶活性的增加可能会降低细胞内游离AA的浓度，从而也降低ROM的产生。这些研究表明了影响ROM生物合成以及可能影响类花生酸生物合成的新可能性，类花生酸在不同肺部疾病中作为致病介质起着重要作用。
