Department of Pneumology, Upper-Silesian Medical Center, Medical University of Silesia, Katowice, Poland.
Department of Epidemiology, Medical University of Silesia, Katowice, Poland.
Adv Exp Med Biol. 2019;1160:19-23. doi: 10.1007/5584_2019_379.
Recently, it has been shown in the murine model that platelet maturation takes place, to some extent, in the lungs. The extrapolation of these findings to humans leads to the possibility that chronic lung diseases could affect platelet maturation and, consequently, the platelet count. The aim of this study was to investigate whether there are changes in the platelet count in patients with chronic obstructive disease (COPD). The study included 44 patients, aged 66.5 ± 5.5 years, in stage II-IV COPD. The control group consisted of 48 age- and gender-matched patients without any respiratory diseases. We failed to find a significant difference in the platelet count between the two groups: 231 ± 80 vs. 223 ± 63 x 10/μL, respectively (p = 0.61). However, the number of platelets in the COPD patients was inversely associated with hemoglobin content (r = -0.57; p < 0.001), hematocrit (r = -0.40; p = 0.006), and the red cell count (r = -0.51; p < 0.001); the blood morphology indices that are typically increased in severe COPD. Such associations were absent in the control non-COPD group. We conclude that COPD has no influence on the platelet count in humans.
最近，在小鼠模型中已经表明，血小板成熟在一定程度上发生在肺部。这些发现的推断导致了这样一种可能性，即慢性肺部疾病可能会影响血小板成熟，从而影响血小板计数。本研究旨在探讨慢性阻塞性肺疾病（COPD）患者的血小板计数是否发生变化。该研究包括 44 名年龄为 66.5±5.5 岁的 II-IV 期 COPD 患者。对照组由 48 名年龄和性别匹配且无任何呼吸系统疾病的患者组成。我们未能发现两组患者的血小板计数有显著差异：分别为 231±80 和 223±63 x 10/μL（p=0.61）。然而，COPD 患者的血小板数量与血红蛋白含量（r=-0.57；p<0.001）、血细胞比容（r=-0.40；p=0.006）和红细胞计数（r=-0.51；p<0.001）呈负相关；这些血液形态学指标在严重 COPD 中通常会增加。在对照组非 COPD 组中不存在这种关联。我们得出结论，COPD 对人类的血小板计数没有影响。
