Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Exp Clin Endocrinol Diabetes. 2021 Jun;129(6):407-412. doi: 10.1055/a-0895-5275. Epub 2019 May 2.
This study explores the association between chronic periodontitis and renal dysfunction in type 2 diabetic mellitus (T2DM) patients.
An observational study was conducted in 169 T2DM patients with chronic periodontitis. Patients were divided into 2 groups according to presence of normal renal function (n=111) and renal dysfunction (n=58), and oral health behavior-related variables were obtained by questionnaire. Periodontal status was examined, and pocket probing depth (PD), clinical attachment level (CAL), and bleeding index (BI) were measured.
The severe periodontitis group had a significant higher HbA1c level (8.53 ± 1.61%) as compared with the mild and moderate periodontitis groups (7.68±1.58%) and (7.35±1.45%), P=0.001. Compared with patients with normal renal function, patients with renal dysfunction had a higher PD value, higher CAL value, fewer remaining teeth, and were less likely to have remaining teeth ≥20. The percentage of sites with PD ≥4 mm (52.8% vs. 41.67%) was significantly greater in patients with renal dysfunction. There was no difference in the scores of oral health knowledge assessment between the 2 groups. After adjustment by gender, age, BMI, smoking, hypertension, and HbA1c, the percentage of the sites with PD≥4 mm was an independent risk factor of renal dysfunction in T2DM patients.
In patients with T2DM, those with periodontitis may be more susceptible to decreased kidney function.
本研究探讨了 2 型糖尿病（T2DM）患者慢性牙周炎与肾功能不全之间的关系。
对 169 例患有慢性牙周炎的 T2DM 患者进行了一项观察性研究。根据肾功能正常（n=111）和肾功能不全（n=58）将患者分为两组，并通过问卷获得与口腔健康行为相关的变量。检查牙周状况，测量探诊深度（PD）、临床附着水平（CAL）和出血指数（BI）。
与轻度和中度牙周炎组（7.68±1.58%和 7.35±1.45%）相比，重度牙周炎组的糖化血红蛋白（HbA1c）水平（8.53±1.61%）显著更高，P=0.001。与肾功能正常的患者相比，肾功能不全的患者 PD 值更高，CAL 值更高，剩余牙齿更少，且剩余牙齿≥20 颗的可能性更小。PD≥4 mm 的位点百分比（52.8% vs. 41.67%）在肾功能不全患者中显著更高。两组口腔健康知识评估得分无差异。在调整性别、年龄、BMI、吸烟、高血压和 HbA1c 后，PD≥4 mm 的位点百分比是 T2DM 患者肾功能不全的独立危险因素。
在 T2DM 患者中，患有牙周炎的患者可能更容易出现肾功能下降。
