Yu Y, Dunaway S, Champer J, Kim J, Alikhan A
Department of Dermatology, University of Cincinnati, Cincinnati, OH, U.S.A.
Department of Computational Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, U.S.A.
Br J Dermatol. 2020 Jan;182(1):39-46. doi: 10.1111/bjd.18088. Epub 2019 Jul 28.
Commensal bacteria are a major factor in human health and disease pathogenesis. Interest has recently expanded beyond the gastrointestinal microbiome to include the skin microbiome and its impact on various skin diseases.
Here we present current data reviewing the role of the microbiome in dermatology, considering both the gut and skin microflora. Our objective was to evaluate whether the clinical data support the utility of oral and topical probiotics for certain dermatological diseases.
The PubMed and ClinicalTrials.gov databases were searched for basic science, translational research and clinical studies that investigated differences in the cutaneous microbiome and the impact of probiotics in patients with atopic dermatitis, acne vulgaris, psoriasis, chronic wounds, seborrhoeic dermatitis and cutaneous neoplasms.
Few clinical trials exist that explore the utility of probiotics for the prevention and treatment of dermatological diseases, with the exception of atopic dermatitis. Most studies investigated oral probiotic interventions, and of those utilizing topical probiotics, few included skin commensals. In general, the available clinical trials yielded positive results with improvement of the skin conditions after probiotic intervention.
Oral and topical probiotics appear to be effective for the treatment of certain inflammatory skin diseases and demonstrate a promising role in wound healing and skin cancer. However, more studies are needed to confirm these results. What's already known about this topic? The microbiome plays a role in human health and disease pathogenesis. Probiotics can manipulate the host microbiome and may confer health benefits for patients. Research to date has already begun to explore the utility of oral and topical probiotics for certain dermatological diseases. What does this study add? This review presents basic science and clinical trial data to support the role of the gut and skin microbiome in dermatology. Current data are reviewed on the use of probiotics in the prevention and treatment of skin diseases, including atopic dermatitis, acne vulgaris, psoriasis, seborrhoeic dermatitis, chronic wounds and cutaneous neoplasms. Future probiotic interventions are proposed.
共生菌是人类健康和疾病发病机制的主要因素。最近，人们的兴趣已从胃肠道微生物群扩展到皮肤微生物群及其对各种皮肤病的影响。
本文介绍了当前关于微生物群在皮肤病学中作用的数据，同时考虑了肠道和皮肤微生物群。我们的目的是评估临床数据是否支持口服和局部使用益生菌治疗某些皮肤病的效用。
检索了PubMed和ClinicalTrials.gov数据库，以查找研究皮肤微生物群差异以及益生菌对特应性皮炎、寻常痤疮、银屑病、慢性伤口、脂溢性皮炎和皮肤肿瘤患者影响的基础科学、转化研究和临床研究。
除了特应性皮炎外，很少有临床试验探讨益生菌在预防和治疗皮肤病方面的效用。大多数研究调查了口服益生菌干预措施，而在那些使用局部益生菌的研究中，很少包括皮肤共生菌。总体而言，现有的临床试验产生了积极的结果，益生菌干预后皮肤状况得到改善。
口服和局部使用益生菌似乎对某些炎症性皮肤病有效，并在伤口愈合和皮肤癌方面显示出有前景的作用。然而，需要更多的研究来证实这些结果。关于这个主题已经知道了什么？微生物群在人类健康和疾病发病机制中起作用。益生菌可以操纵宿主微生物群，并可能为患者带来健康益处。迄今为止的研究已经开始探索口服和局部使用益生菌治疗某些皮肤病的效用。这项研究增加了什么？本综述提供了基础科学和临床试验数据，以支持肠道和皮肤微生物群在皮肤病学中的作用。综述了益生菌在预防和治疗皮肤病（包括特应性皮炎、寻常痤疮、银屑病、脂溢性皮炎、慢性伤口和皮肤肿瘤）方面的现有数据。提出了未来的益生菌干预措施。
