Habeebuddin Mohammed, Karnati Ranjith Kumar, Shiroorkar Predeepkumar Narayanappa, Nagaraja Sreeharsha, Asdaq Syed Mohammed Basheeruddin, Khalid Anwer Md, Fattepur Santosh
Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Hofuf 31982, Saudi Arabia.
Department of Chemistry, College of Science, King Faisal University, Al-Hofuf 31982, Saudi Arabia.
Pharmaceutics. 2022 Mar 3;14(3):557. doi: 10.3390/pharmaceutics14030557.
Skin, an exterior interface of the human body is home to commensal microbiota and also acts a physical barrier that protects from invasion of foreign pathogenic microorganisms. In recent years, interest has significantly expanded beyond the gut microbiome to include the skin microbiome and its influence in managing several skin disorders. Probiotics play a major role in maintaining human health and disease prevention. Topical probiotics have demonstrated beneficial effects for the treatment of certain inflammatory skin diseases such as acne, rosacea, psoriasis etc., and also found to have a promising role in wound healing. In this review, we discuss recent insights into applications of topical probiotics and their influence on health and diseases of the skin. Patents, commercially available topical probiotics, and novel probiotic impregnated fabrics have been emphasized. A thorough understanding of the relationship between probiotics and the skin microbiome is important for designing novel therapeutic approaches in using topical probiotics.
皮肤作为人体的外部界面，是共生微生物群的家园，同时也作为一道物理屏障，防止外来致病微生物的入侵。近年来，人们的兴趣已从肠道微生物群显著扩展到包括皮肤微生物群及其在管理多种皮肤疾病中的影响。益生菌在维持人类健康和疾病预防中发挥着重要作用。局部应用益生菌已显示出对治疗某些炎症性皮肤病（如痤疮、酒渣鼻、牛皮癣等）具有有益效果，并且还发现在伤口愈合中具有广阔前景。在这篇综述中，我们讨论了局部应用益生菌的最新见解及其对皮肤健康和疾病的影响。文中强调了相关专利、市售的局部应用益生菌以及新型含益生菌的织物。深入了解益生菌与皮肤微生物群之间的关系对于设计使用局部应用益生菌的新型治疗方法至关重要。
