Hardy R R, Hayakawa K, Shimizu M, Yamasaki K, Kishimoto T
Science. 1987 Apr 3;236(4797):81-3. doi: 10.1126/science.3105057.
A human B cell subpopulation identifiable by the expression of the cell surface antigen Leu-1 (CD5) is responsible for most of the immunoglobulin M rheumatoid factor secreted in vitro after the cells are stimulated with Staphylococcus aureus. The ability of B cells bearing the Leu-1 marker (Leu-1+) to secrete rheumatoid factor is present early in development and extends to adulthood, since Leu-1+ B cells from cord blood and from peripheral blood lymphocytes of both normal adults and patients with certain autoimmune conditions secrete rheumatoid factor in comparable amounts. The neonatal enrichment of Leu-1+ B cells, the presence of Leu-1+ B cells in increased frequencies in patients with autoimmune disease, and the involvement of Leu-1+ B cells in autoantibody secretion suggest both developmental and functional homologies between this human B cell subpopulation and the murine Ly-1 B cell subpopulation.
一种可通过细胞表面抗原Leu-1（CD5）的表达来识别的人类B细胞亚群，在细胞受到金黄色葡萄球菌刺激后，负责体外分泌的大部分免疫球蛋白M类风湿因子。携带Leu-1标记（Leu-1+）的B细胞分泌类风湿因子的能力在发育早期就存在，并持续到成年期，因为来自脐带血以及正常成年人和某些自身免疫性疾病患者外周血淋巴细胞中的Leu-1+B细胞分泌类风湿因子的量相当。新生儿中Leu-1+B细胞的富集、自身免疫性疾病患者中Leu-1+B细胞频率的增加以及Leu-1+B细胞参与自身抗体分泌，表明该人类B细胞亚群与小鼠Ly-1 B细胞亚群在发育和功能上具有同源性。
