Simeonov Svilen P, Ravutsov Martin A, Mihovilovic Marko D
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bontchev str. Bl. 9, 1113, Sofia, Bulgaria.
Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060, Wien, Austria.
ChemSusChem. 2019 Jun 21;12(12):2748-2754. doi: 10.1002/cssc.201900601. Epub 2019 Jun 6.
A new scalable synthesis of pentane-1,2,5-triol from the furanics platform has been developed. Excellent yields of up to 92 % are obtained under flow conditions by using readily available catalysts from the existing pool. The strategy exploits the highly functionalized Achmatowicz product as a key intermediate, thus circumventing problems related to the low reactivity of the parent furfural and furfuryl alcohol. Besides expanding the portfolio of biomass-derived C alcohols, this strategy may also be further applied for the establishment of a versatile bio-based chemical platform.
已开发出一种从呋喃类平台合成戊烷-1,2,5-三醇的新型可扩展方法。在流动条件下，使用现有库存中容易获得的催化剂，可获得高达92%的优异产率。该策略利用高度官能化的阿赫马托维奇产物作为关键中间体，从而规避了与母体糠醛和糠醇低反应性相关的问题。除了扩大生物质衍生的C醇产品组合外，该策略还可进一步应用于建立一个通用的生物基化学平台。
