• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于递送阿霉素的天然物质功能性纳米凝胶

Functional Nanogel from Natural Substances for Delivery of Doxorubicin.

作者信息

Kamenova Katya, Radeva Lyubomira, Yoncheva Krassimira, Ublekov Filip, Ravutsov Martin A, Marinova Maya K, Simeonov Svilen P, Forys Aleksander, Trzebicka Barbara, Petrov Petar D

机构信息

Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.

出版信息

Polymers (Basel). 2022 Sep 5;14(17):3694. doi: 10.3390/polym14173694.

DOI:10.3390/polym14173694
PMID:36080768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9459996/
Abstract

Nanogels (NGs) have attracted great attention because of their outstanding biocompatibility, biodegradability, very low toxicity, flexibility, and softness. NGs are characterized with a low and nonspecific interaction with blood proteins, meaning that they do not induce any immunological responses in the body. Due to these properties, NGs are considered promising candidates for pharmaceutical and biomedical application. In this work, we introduce the development of novel functional nanogel obtained from two naturally based products-citric acid (CA) and pentane-1,2,5-triol (PT). The nanogel was synthesized by precipitation esterification reaction of CA and PT in tetrahydrofuran using N-ethyl-N'-(3-dimethylaminopropyl) carbodiimide (EDC) and 4-(dimethylamino)pyridine (DMAP) catalyst system. Dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM) and atomic force microscopy (AFM) analyses revealed formation of spherical nanogel particles with a negative surface charge. Next, the nanogel was loaded with doxorubicin hydrochloride (DOX) by electrostatic interactions between carboxylic groups present in the nanogel and amino groups of DOX. The drug-loaded nanogel exhibited high encapsulation efficiency (EE~95%), and a bi-phasic release behavior. Embedding DOX into nanogel also stabilized the drug against photodegradation. The degradability of nanogel under acidic and neutral conditions with time was investigated as well.

摘要

纳米凝胶（NGs）因其出色的生物相容性、生物可降解性、极低的毒性、柔韧性和柔软性而备受关注。纳米凝胶的特点是与血液蛋白的相互作用较低且无特异性，这意味着它们不会在体内引发任何免疫反应。由于这些特性，纳米凝胶被认为是药物和生物医学应用的有前途的候选者。在这项工作中，我们介绍了一种新型功能纳米凝胶的开发，该纳米凝胶由两种天然基产品——柠檬酸（CA）和戊烷-1,2,5-三醇（PT）制成。通过在四氢呋喃中使用N-乙基-N'-(3-二甲基氨基丙基)碳二亚胺（EDC）和4-(二甲基氨基)吡啶（DMAP）催化剂体系，使CA和PT发生沉淀酯化反应来合成纳米凝胶。动态光散射（DLS）、低温透射电子显微镜（cryo-TEM）和原子力显微镜（AFM）分析表明形成了具有负表面电荷的球形纳米凝胶颗粒。接下来，通过纳米凝胶中存在的羧基与盐酸多柔比星（DOX）的氨基之间的静电相互作用，将盐酸多柔比星（DOX）负载到纳米凝胶中。载药纳米凝胶表现出高包封率（EE~95%）和双相释放行为。将DOX包埋到纳米凝胶中还使药物对光降解具有稳定性。还研究了纳米凝胶在酸性和中性条件下随时间的降解性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/8abbe9e090bf/polymers-14-03694-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/5b8552debc27/polymers-14-03694-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/86a5af4bfab2/polymers-14-03694-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/d70dd16cc2c1/polymers-14-03694-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/5eba7269b2df/polymers-14-03694-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/eff512120bf8/polymers-14-03694-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/d735fb7fb155/polymers-14-03694-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/7d39ca4976e3/polymers-14-03694-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/8abbe9e090bf/polymers-14-03694-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/5b8552debc27/polymers-14-03694-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/86a5af4bfab2/polymers-14-03694-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/d70dd16cc2c1/polymers-14-03694-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/5eba7269b2df/polymers-14-03694-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/eff512120bf8/polymers-14-03694-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/d735fb7fb155/polymers-14-03694-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/7d39ca4976e3/polymers-14-03694-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9d0/9459996/8abbe9e090bf/polymers-14-03694-g008.jpg

相似文献

1
Functional Nanogel from Natural Substances for Delivery of Doxorubicin.用于递送阿霉素的天然物质功能性纳米凝胶
Polymers (Basel). 2022 Sep 5;14(17):3694. doi: 10.3390/polym14173694.
2
Incorporation of Resveratrol in Polymeric Nanogel for Improvement of Its Protective Effects on Cellular and Microsomal Oxidative Stress Models.白藜芦醇掺入聚合物纳米凝胶以增强其对细胞和微粒体氧化应激模型的保护作用。
Gels. 2023 May 30;9(6):450. doi: 10.3390/gels9060450.
3
A glutathione-responsive PEGylated nanogel with doxorubicin-conjugation for cancer therapy.一种用于癌症治疗的、与阿霉素偶联的谷胱甘肽响应性聚乙二醇化纳米凝胶。
J Mater Chem B. 2023 Dec 13;11(48):11612-11619. doi: 10.1039/d3tb01731a.
4
Synthesis of a novel thermo/pH sensitive nanogel based on salep modified graphene oxide for drug release.基于角叉菜胶修饰氧化石墨烯的新型温敏/ pH敏感纳米凝胶用于药物释放的合成
Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:558-565. doi: 10.1016/j.msec.2016.11.109. Epub 2016 Nov 30.
5
Preparation of thermo/redox/pH-stimulative poly(N-isopropylacrylamide-co-N,N'-dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors.温敏/氧化还原/pH 刺激型聚（N-异丙基丙烯酰胺-co-N,N'-二甲氨基乙基甲基丙烯酰胺）纳米凝胶的制备及其 DOX 释放行为。
J Biomed Mater Res A. 2019 Jun;107(6):1195-1203. doi: 10.1002/jbm.a.36611. Epub 2019 Jan 31.
6
pH responsive biodegradable nanogels for sustained release of bleomycin.用于博来霉素持续释放的pH响应性可生物降解纳米凝胶
Bioorg Med Chem. 2017 Sep 1;25(17):4595-4613. doi: 10.1016/j.bmc.2017.06.038. Epub 2017 Jun 27.
7
Biocompatible nanogel derived from functionalized dextrin for targeted delivery of doxorubicin hydrochloride to MG 63 cancer cells.由功能化糊精衍生的生物相容性纳米凝胶，用于盐酸多柔比星靶向递送至 MG63 癌细胞。
Carbohydr Polym. 2017 Sep 1;171:27-38. doi: 10.1016/j.carbpol.2017.04.068. Epub 2017 Apr 27.
8
Charge-conversional and reduction-sensitive poly(vinyl alcohol) nanogels for enhanced cell uptake and efficient intracellular doxorubicin release.用于增强细胞摄取和高效细胞内阿霉素释放的荷电化及还原敏感型聚乙烯醇纳米凝胶。
J Control Release. 2015 May 10;205:15-24. doi: 10.1016/j.jconrel.2014.11.012. Epub 2014 Nov 20.
9
Construction and Performance Evaluation of (Linn.) Gaertn. Polysaccharide-Based Nanogel.基于（林奈）加尔特纳多糖的纳米凝胶的构建与性能评估。
Polymers (Basel). 2023 Apr 19;15(8):1933. doi: 10.3390/polym15081933.
10
A facile approach for thermal and reduction dual-responsive prodrug nanogels for intracellular doxorubicin delivery.一种用于细胞内阿霉素递送的热响应和还原双响应前药纳米凝胶的简便方法。
J Mater Chem B. 2016 Dec 21;4(47):7572-7583. doi: 10.1039/c6tb01285j. Epub 2016 Nov 14.

引用本文的文献

1
Graphene Oxide: Preparation and Medical Research.氧化石墨烯：制备与医学研究。
Materials (Basel). 2025 Jun 17;18(12):2855. doi: 10.3390/ma18122855.
2
Nanogels-Innovative Drug Carriers for Overcoming Biological Membranes.纳米凝胶——用于跨越生物膜的创新药物载体
Gels. 2025 Feb 8;11(2):124. doi: 10.3390/gels11020124.
3
Facile synthesis of elastin nanogels encapsulated decursin for castrated resistance prostate cancer therapy.弹性蛋白纳米凝胶包封升麻苷用于去势抵抗性前列腺癌治疗的简便合成。

本文引用的文献

1
Precipitation Polymerization: A Powerful Tool for Preparation of Uniform Polymer Particles.沉淀聚合：制备均匀聚合物颗粒的强大工具。
Polymers (Basel). 2022 Apr 30;14(9):1851. doi: 10.3390/polym14091851.
2
Highly Elastic Super-Macroporous Cryogels Fabricated by Thermally Induced Crosslinking of 2-Hydroxyethylcellulose with Citric Acid in Solid State.固相热引发羟乙基纤维素与柠檬酸交联制备高弹性超大孔冷冻凝胶。
Molecules. 2021 Oct 21;26(21):6370. doi: 10.3390/molecules26216370.
3
Degradation-Dependent Controlled Delivery of Doxorubicin by Glyoxal Cross-Linked Magnetic and Porous Chitosan Microspheres.
Sci Rep. 2024 Jul 2;14(1):15095. doi: 10.1038/s41598-024-65999-x.
4
Functional Hydrogels for Delivery of the Proteolytic Enzyme Serratiopeptidase.用于递送蛋白水解酶沙雷肽酶的功能性水凝胶
Gels. 2024 Feb 20;10(3):156. doi: 10.3390/gels10030156.
5
Biopolymeric Nanogel as a Drug Delivery System for Doxorubicin-Improved Drug Stability and Enhanced Antineoplastic Activity in Skin Cancer Cells.生物聚合物纳米凝胶作为阿霉素的药物递送系统——改善药物稳定性并增强对皮肤癌细胞的抗肿瘤活性
Pharmaceuticals (Basel). 2024 Jan 31;17(2):186. doi: 10.3390/ph17020186.
6
Incorporation of Resveratrol in Polymeric Nanogel for Improvement of Its Protective Effects on Cellular and Microsomal Oxidative Stress Models.白藜芦醇掺入聚合物纳米凝胶以增强其对细胞和微粒体氧化应激模型的保护作用。
Gels. 2023 May 30;9(6):450. doi: 10.3390/gels9060450.
7
Nano-Gels: Recent Advancement in Fabrication Methods for Mitigation of Skin Cancer.纳米凝胶：减轻皮肤癌的制备方法的最新进展
Gels. 2023 Apr 13;9(4):331. doi: 10.3390/gels9040331.
乙二醛交联磁性多孔壳聚糖微球对阿霉素的降解依赖性控释
ACS Omega. 2021 Aug 9;6(33):21472-21484. doi: 10.1021/acsomega.1c02303. eCollection 2021 Aug 24.
4
Tunable Polyglycerol-Based Redox-Responsive Nanogels for Efficient Cytochrome C Delivery.用于高效递送细胞色素C的可调节聚甘油基氧化还原响应纳米凝胶
Pharmaceutics. 2021 Aug 17;13(8):1276. doi: 10.3390/pharmaceutics13081276.
5
An improved method in fabrication of smart dual-responsive nanogels for controlled release of doxorubicin and curcumin in HT-29 colon cancer cells.一种改良的方法用于制备智能双响应纳米凝胶，以控制在 HT-29 结肠癌细胞中阿霉素和姜黄素的释放。
J Nanobiotechnology. 2021 Jan 9;19(1):18. doi: 10.1186/s12951-020-00764-6.
6
Chemical Architecture of Block Copolymers Differentially Abrogate Cardiotoxicity and Maintain the Anticancer Efficacy of Doxorubicin.嵌段共聚物的化学结构差异消除心脏毒性并保持多柔比星的抗癌疗效。
Mol Pharm. 2020 Dec 7;17(12):4676-4690. doi: 10.1021/acs.molpharmaceut.0c00963. Epub 2020 Nov 5.
7
Biorefinery via Achmatowicz Rearrangement: Synthesis of Pentane-1,2,5-triol from Furfuryl Alcohol.通过阿赫马托维茨重排实现生物炼制：由糠醇合成1,2,5-戊三醇
ChemSusChem. 2019 Jun 21;12(12):2748-2754. doi: 10.1002/cssc.201900601. Epub 2019 Jun 6.
8
Highly photostable nanogels for fluorescence-based theranostics.用于基于荧光的诊疗的高光稳定性纳米凝胶。
Bioact Mater. 2018 Mar;3(1):39-47. doi: 10.1016/j.bioactmat.2017.03.001. Epub 2017 Mar 27.
9
Four new degradation products of doxorubicin: An application of forced degradation study and hyphenated chromatographic techniques.阿霉素的四种新降解产物：强制降解研究与联用色谱技术的应用
J Pharm Anal. 2015 Oct;5(5):285-295. doi: 10.1016/j.jpha.2015.05.003. Epub 2015 May 23.
10
Bio-responsive alginate-keratin composite nanogels with enhanced drug loading efficiency for cancer therapy.具有增强药物负载效率的生物响应性藻酸盐-角蛋白复合纳米凝胶用于癌症治疗。
Carbohydr Polym. 2017 Nov 1;175:159-169. doi: 10.1016/j.carbpol.2017.07.078. Epub 2017 Jul 29.