Krasnewich D, Kozak C A, Nebert D W, Mackenzie P I
Somat Cell Mol Genet. 1987 Mar;13(2):179-82. doi: 10.1007/BF01534698.
The drug-metabolizing UDP glucuronosyltransferases are encoded by genes which constitute a multigene family. One rat gene subfamily codes for at least four constitutive enzyme forms, including those which glucuronidate the androgenic steroids testosterone (UDPGTr-3) and androsterone (UDPGTr-4). In the present study, UDPGTr-3 and UDPGTr-4 cDNAs were used to demonstrate that an homologous subfamily is present in the mouse genome. Using mouse X Chinese hamster somatic cell hybrids, we mapped at least one gene of this UDP glucuronosyltransferase subfamily (UDPGTr-3) to mouse chromosome 5 and suggest the name as the Udpgt-3 locus.
药物代谢UDP葡萄糖醛酸转移酶由构成多基因家族的基因编码。一个大鼠基因亚家族编码至少四种组成型酶形式，包括那些使雄激素类固醇睾酮（UDPGTr - 3）和雄酮（UDPGTr - 4）葡萄糖醛酸化的酶。在本研究中，UDPGTr - 3和UDPGTr - 4的cDNA被用于证明小鼠基因组中存在同源亚家族。利用小鼠×中国仓鼠体细胞杂种，我们将这个UDP葡萄糖醛酸转移酶亚家族的至少一个基因（UDPGTr - 3）定位到小鼠5号染色体上，并建议将其命名为Udpgt - 3基因座。
