Sato H, Ito M, Abe T, Kumano N, Motomiya M, Konno K
Tohoku J Exp Med. 1986 Dec;150(4):391-9. doi: 10.1620/tjem.150.391.
The antitumor activity of lipopolysaccharide (LPS) was investigated in BCG-treated mice. C3H/He mice and CDF1 mice were injected with BCG and then were inoculated with syngeneic mouse hepatoma MH134 and mastocytoma P815 respectively. Hemorrhagic necrosis and retarded growth of tumor were observed after an intravenous (i.v.) injection of LPS, when tumor cells had been inoculated subcutaneously (s.c.). However an intraperitoneal (i.p.) injection of BCG plus LPS did not increase the mean survival time of mice that had been inoculated with tumor cells i.p. Sera from mice that had been treated with BCG plus LPS i.v. were cytotoxic for cultured tumor cells. These results seemed to indicate that growth-inhibitory effects of LPS on tumors inoculated s.c. were mediated by a humoral factor.
在经卡介苗（BCG）处理的小鼠中研究了脂多糖（LPS）的抗肿瘤活性。给C3H/He小鼠和CDF1小鼠注射卡介苗，然后分别接种同基因小鼠肝癌MH134和肥大细胞瘤P815。当肿瘤细胞已皮下接种时，静脉注射LPS后观察到肿瘤出现出血性坏死和生长迟缓。然而，腹腔注射卡介苗加LPS并未增加经腹腔接种肿瘤细胞的小鼠的平均存活时间。经静脉注射卡介苗加LPS处理的小鼠的血清对培养的肿瘤细胞具有细胞毒性。这些结果似乎表明，LPS对皮下接种肿瘤的生长抑制作用是由一种体液因子介导的。
