Malaria is a dangerous disease affecting humans and animals in tropical and subtropical areas worldwide. According to recent estimates, 3.2 billion people are at risk of malaria. Many drugs are in practices to control this disease and their vectors. Eco-friendly control tools are needed to fight vectors of this important disease. Nanotechnology is playing a key role in the fight against many public health emergencies. In the present study, aqueous peel extract was used to prepare zinc oxide nanoparticles (ZnO NPs), then tested on eggs, larvae and pupae. The -synthesised ZnO NPs were characterized additionally by FTIR, AFM, XRD, UV-Vis spectroscopy, EDX, and SEM spectroscopy The ovicidal, larvicidal, pupicidal and repellent activities of and green-synthesised ZnO NPs were analysed on . The potential mechanism of action of ZnO NPs was studied investigating the changes in various enzyme activities in IV instar larvae. Furthermore, the smoke toxicity of -based cones against A. stephensi evoked higher mortality if compared with the control. Overall, the present study concluded that peel extract and its mediated green synthesised ZnO NPs represent a valuable green option to manage against malaria vectors.