Gadzhieva Z M, Lashneva N V, Khan A V
Vopr Pitan. 1987 Jan-Feb(1):45-50.
In is shown that administration of sovol, a mixture of polychlorinated diphenyls, in a dose of 500 mg/kg (about 1:10 LD50) induces pronounced changes in the rat liver structure, in particular, fat accumulation and diminution of RNA lump number in hepatocyte cytoplasma, alteration of nuclei, decrease in the number of hepatocytes and binuclear cells in the visual field. Structural disorders in the liver are observed during a long period (up to 5 months) and, to a certain extent, depend on the composition of the lipid component of the ration. Certain differences are recorded in the character of the morphological changes in the liver after single and repeated injections of the agent. No distinct relationship is recorded between the manifestation of hepatocyte fat infiltration and other morphological changes in the liver, and the index of microsomal cytochrome P-450 induction during sovol action.
结果表明，给予大鼠剂量为500毫克/千克（约为半数致死量的1:10）的多氯联苯混合物sovol，会引起大鼠肝脏结构的显著变化，特别是脂肪堆积、肝细胞胞质中RNA团块数量减少、细胞核改变、视野中肝细胞和双核细胞数量减少。肝脏结构紊乱在很长一段时间内（长达5个月）都能观察到，并且在一定程度上取决于日粮脂质成分的组成。单次和重复注射该药剂后，肝脏形态学变化特征存在某些差异。在sovol作用期间，未发现肝细胞脂肪浸润表现与肝脏其他形态学变化以及微粒体细胞色素P-450诱导指数之间存在明显关系。
