[Effect of ionol on cytochrome P-450 induction in the liver of rats by polychlorinated biphenyls].

A single oral administration of a mixture of polychlorinated diphenyls (50 and mg/kg) leads to a dose-dependent increase in the cytochrome P-450 content in rat liver. The synthetic antioxidant ionol administered singly and repeatedly (30 mg/kg) does not exert any substantial influence on the hemoprotein content in the liver. Preliminary administration of ionol potentiates the action of the mixture of polychlorinated diphenyls on cytochrome P-450 induction in the liver of experimental animals.