[Effect of ionol on cytochrome P-450 induction in the liver of rats by polychlorinated biphenyls].
作者信息
Khan A V, Lashneva N V, Kumok S T, Gurbivh Ia A, Tutel'ian V A
出版信息
Vopr Pitan. 1985 Jul-Aug(4):66-9.
PMID:3933179
Abstract
A single oral administration of a mixture of polychlorinated diphenyls (50 and mg/kg) leads to a dose-dependent increase in the cytochrome P-450 content in rat liver. The synthetic antioxidant ionol administered singly and repeatedly (30 mg/kg) does not exert any substantial influence on the hemoprotein content in the liver. Preliminary administration of ionol potentiates the action of the mixture of polychlorinated diphenyls on cytochrome P-450 induction in the liver of experimental animals.
摘要
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