血清视黄醇而非 25(OH)D 状态与老年墨西哥成年人的血清铁调素水平相关。

Serum Retinol but Not 25(OH)D Status Is Associated With Serum Hepcidin Levels in Older Mexican Adults.

Center for Evaluation and Survey Research, National Institute of Public Health, Cuernavaca 62100, Mexico.

Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca 62100, Mexico.

Nutrients. 2019 Apr 30;11(5):988. doi: 10.3390/nu11050988.

Abstract

Background: Elevated hepcidin levels have been linked to anemia of inflammation (AI). Retinol deficiency has shown to upregulate hepcidin expression in animals, while conflicting evidence links VD status with hepcidin concentration in humans. The purpose of the study is to explore if VA and VD status are associated with hepcidin concentrations in older Mexican adults (OA). 2) Methods: A cross-sectional study was conducted in summer 2015, using serum samples from 783 fasting OA ages 60 and above residents from Campeche and Yucatán. VA deficiency (VAD) was defined as serum retinol concentration <20 μg/dL and VD deficiency (VDD) as 25(OH)D <50 nmol/L. The log-hepcidin was the outcome variable expressed as continuous and tertiles of its distribution. Linear and ordinal regression models were used. 3) Results: VAD was present in 3.4% and VDD in 9.5% of OA. Log-retinol was inversely associated with log-hepcidin (coeff.: -0.15, 95%CI: -0.2, -0.09). VAD status shown a higher probability than non-VAD for higher hepcidin tertiles (OR = 2.15, 95%CI: 1.24, 3.74). VDD states was not associated with hepcidin in the linear (coeff.: 0.16, 95%CI: -0.02, 0.34) nor the ordinal model (OR = 0.74, 95%CI: 0.42, 1.28). 4) Conclusions: VAD, but not VDD, status was inversely associated with hepcidin concentrations in OA.

摘要

背景：铁调素水平升高与炎症性贫血（AI）有关。维生素 A 缺乏已显示出在动物中上调铁调素的表达，而有冲突的证据表明维生素 D 状态与人类铁调素浓度有关。本研究的目的是探讨维生素 A 和 D 状态是否与老年墨西哥成年人（OA）的铁调素浓度有关。
方法：2015 年夏季进行了一项横断面研究，使用来自坎佩切和尤卡坦州 783 名空腹 OA（年龄在 60 岁及以上）居民的血清样本。维生素 A 缺乏（VAD）定义为血清视黄醇浓度<20μg/dL，维生素 D 缺乏（VDD）定义为 25（OH）D<50nmol/L。铁调素的对数为连续变量，并按其分布的三分位数表示。使用线性和有序回归模型。
结果：OA 中 VAD 发生率为 3.4%，VDD 发生率为 9.5%。log 视黄醇与 log 铁调素呈负相关（系数：-0.15，95%CI：-0.2，-0.09）。与非 VAD 状态相比，VAD 状态更有可能处于较高的铁调素三分位数（OR=2.15，95%CI：1.24，3.74）。线性（系数：0.16，95%CI：0.02，0.34）和有序模型（OR=0.74，95%CI：0.42，1.28）均未显示 VDD 状态与铁调素相关。
结论：VAD 状态，但不是 VDD 状态，与 OA 中的铁调素浓度呈负相关。