Department of Neurology, University Clinic Heidelberg, 69120 Heidelberg, Germany.
Clinical Cooperation Unit (CCU) Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DFKZ), 69120 Heidelberg, Germany.
Int J Mol Sci. 2019 Apr 30;20(9):2146. doi: 10.3390/ijms20092146.
Neuronal subpopulations display differential vulnerabilities to disease, but the factors that determine their susceptibility are poorly understood. Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important first line of defense through their ability to buffer incoming calcium, allowing the neuron to quickly achieve homeostasis. Since neurons expressing different calcium-binding proteins have been reported to be differentially susceptible to degeneration, it can be hypothesized that rather than just serving as markers of different neuronal subpopulations, they might actually be a key determinant of survival. In this review, we will summarize some of the evidence that expression of the EF-hand calcium-binding proteins, calbindin, calretinin and parvalbumin, may influence the susceptibility of distinct neuronal subpopulations to disease processes.
神经元亚群对疾病表现出不同的易感性，但决定其易感性的因素知之甚少。细胞内钙浓度的升高是几种神经退行性过程的一个关键因素，钙结合蛋白通过缓冲传入的钙提供了重要的第一道防线，使神经元能够迅速达到体内平衡。由于报道称表达不同钙结合蛋白的神经元对退化的敏感性不同，因此可以假设，这些蛋白不仅仅是不同神经元亚群的标志物，实际上可能是生存的关键决定因素。在这篇综述中，我们将总结一些证据，表明 EF 手钙结合蛋白钙结合蛋白、钙结合蛋白和钙调蛋白的表达可能影响不同神经元亚群对疾病过程的易感性。
