涂覆有二氧化硅亚微米颗粒的基于微结构光波导的内窥镜探头。

Microstructured Optical Waveguide-Based Endoscopic Probe Coated with Silica Submicron Particles.

作者信息

Ermatov Timur, Petrov Yury V, German Sergei V, Zanishevskaya Anastasia A, Shuvalov Andrey A, Аtkin Vsevolod, Zakharevich Andrey, Khlebtsov Boris N, Skibina Julia S, Ginzburg Pavel, Noskov Roman E, Tuchin Valery V, Gorin Dmitry A

机构信息

Skolkovo Institute of Science and Technology, 3 Nobelya str., 121205 Moscow, Russia.

Department of Physics, Institute of Nanostructures and Biosystems, Saratov State University, 83 Astrakhanskaya str., 410012 Saratov, Russia.

出版信息

Materials (Basel). 2019 May 1;12(9):1424. doi: 10.3390/ma12091424.

DOI:10.3390/ma12091424

PMID:31052408

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6539507/

Abstract

Microstructured optical waveguides (MOW) are of great interest for chemical and biological sensing. Due to the high overlap between a guiding light mode and an analyte filling of one or several fiber capillaries, such systems are able to provide strong sensitivity with respect to variations in the refractive index and the thickness of filling materials. Here, we introduce a novel type of functionalized MOWs whose capillaries are coated by a layer-by-layer (LBL) approach, enabling the alternate deposition of silica particles (SiO) at different diameters-300 nm, 420 nm, and 900 nm-and layers of poly(diallyldimethylammonium chloride) (PDDA). We demonstrate up to three covering bilayers consisting of 300-nm silica particles. Modifications in the MOW transmission spectrum induced by coating are measured and analyzed. The proposed technique of MOW functionalization allows one to reach novel sensing capabilities, including an increase in the effective sensing area and the provision of a convenient scaffold for the attachment of long molecules such as proteins.

摘要

微结构光波导（MOW）在化学和生物传感领域具有极大的吸引力。由于导光模式与一根或几根光纤毛细管中的分析物填充物之间具有高度重叠，此类系统能够针对填充材料的折射率和厚度变化提供高灵敏度。在此，我们介绍一种新型的功能化MOW，其毛细管采用逐层（LBL）方法进行涂层处理，能够交替沉积不同直径（300 nm、420 nm和900 nm）的二氧化硅颗粒（SiO）以及聚二烯丙基二甲基氯化铵（PDDA）层。我们展示了由300 nm二氧化硅颗粒组成的多达三层覆盖双层结构。对涂层引起的MOW传输光谱变化进行了测量和分析。所提出的MOW功能化技术使人们能够实现新的传感能力，包括增加有效传感面积以及为附着蛋白质等长分子提供便利的支架。