Takayama H, Konami T, Konishi T, Pak K, Tomoyoshi T
Hinyokika Kiyo. 1986 Oct;32(10):1449-53.
The concentration of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT), 5-fluorouracil (5-FU) and uracil in blood, the bladder tumor tissue and the bladder mucosa after oral administration of 600 mg per day of UFT for 7 consecutive days was examined in 10 cases of bladder tumors. The concentration of FT and uracil in the tumor tissue did not significantly increase as compared with that in the blood and the bladder mucosa. However, the concentration of 5-FU in the tumor tissue remarkably increased and was 10.7 and 4 times as much as that in the blood and the bladder mucosa, respectively. These results show that administration of UFT meaningfully increases the 5-FU content in bladder tumors and enhances the antitumor activity.
对10例膀胱肿瘤患者连续7天每天口服600毫克优福定（UFT）后，检测血液、膀胱肿瘤组织及膀胱黏膜中1-(2-四氢呋喃基)-5-氟尿嘧啶（FT）、5-氟尿嘧啶（5-FU）和尿嘧啶的浓度。与血液和膀胱黏膜相比，肿瘤组织中FT和尿嘧啶的浓度未显著升高。然而，肿瘤组织中5-FU的浓度显著升高，分别是血液和膀胱黏膜中5-FU浓度的10.7倍和4倍。这些结果表明，服用优福定可有效提高膀胱肿瘤中5-FU的含量并增强抗肿瘤活性。
