Takeyama M, Honjoh M, Ohnishi N, Ishikawa Y, Sakaguchi H, Hanai J
Dept. of Urology, Sakai Municipal Hospital.
Gan To Kagaku Ryoho. 1993 Oct;20(13):1953-9.
The relationship between the 5-FU concentration and tissue degeneration was studied in the bladder tumor tissue after UFT administration. In 12 patients with bladder tumor, UFT 400 mg/day was administered orally for about 2 weeks before TUR, and tegaful, 5-FU and uracil concentrations were examined in the blood and the tumor tissue taken about 6 hours after the last administration. Tumor tissue was also taken before and after the UFT administration, and the degree of cell degeneration due to UFT administration were evaluated by light and electron microscopy. The 5-FU concentration was significantly higher in the tumor tissue (0.078 +/- 0.091 microgram/g) than in the serum (0.017 +/- 0.010 microgram/ml). Signs of degeneration were observed in tumor cells after UFT administration in all 6 patients in whom the tumor tissue 5-FU concentration was 0.046 microgram/g or higher. Mitosis was not increased after UFT administration in any of the 12 patients.
研究了给予优福定（UFT）后膀胱肿瘤组织中5-氟尿嘧啶（5-FU）浓度与组织变性之间的关系。在12例膀胱肿瘤患者中，于经尿道膀胱肿瘤切除术（TUR）前约2周口服优福定400mg/天，末次给药约6小时后采集血液和肿瘤组织，检测替加氟、5-FU和尿嘧啶的浓度。在给予优福定前后也采集肿瘤组织，通过光学显微镜和电子显微镜评估优福定给药引起的细胞变性程度。肿瘤组织中5-FU浓度（0.078±0.091微克/克）显著高于血清（0.017±0.010微克/毫升）。在肿瘤组织5-FU浓度为0.046微克/克或更高的所有6例患者中，给予优福定后均观察到肿瘤细胞变性迹象。12例患者中，给予优福定后有丝分裂均未增加。
