真核生物中的 RNA 聚合酶 II 核心启动子
The RNA Polymerase II Core Promoter in .
机构信息
Section of Molecular Biology, University of California, San Diego, La Jolla, California 92093-0347.
Section of Molecular Biology, University of California, San Diego, La Jolla, California 92093-0347
出版信息
Genetics. 2019 May;212(1):13-24. doi: 10.1534/genetics.119.302021.
Transcription by RNA polymerase II initiates at the core promoter, which is sometimes referred to as the "gateway to transcription." Here, we describe the properties of the RNA polymerase II core promoter in The core promoter is at a strategic position in the expression of genes, as it is the site of convergence of the signals that lead to transcriptional activation. Importantly, core promoters are diverse in terms of their structure and function. They are composed of various combinations of sequence motifs such as the TATA box, initiator (Inr), and downstream core promoter element (DPE). Different types of core promoters are transcribed via distinct mechanisms. Moreover, some transcriptional enhancers exhibit specificity for particular types of core promoters. These findings indicate that the core promoter is a central component of the transcriptional apparatus that regulates gene expression.
RNA 聚合酶 II 通过转录起始于核心启动子，核心启动子有时也被称为“转录的入口”。在这里，我们描述了 RNA 聚合酶 II 核心启动子的特性。核心启动子在基因表达中处于战略位置，因为它是导致转录激活的信号汇聚的位点。重要的是，核心启动子在结构和功能上是多样化的。它们由各种序列基序组成，如 TATA 盒、起始子 (Inr) 和下游核心启动子元件 (DPE)。不同类型的核心启动子通过不同的机制进行转录。此外，一些转录增强子对特定类型的核心启动子表现出特异性。这些发现表明，核心启动子是调节基因表达的转录装置的核心组成部分。
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