Vo Ngoc Long, Wang Yuan-Liang, Kassavetis George A, Kadonaga James T
Section of Molecular Biology, University of California at San Diego, La Jolla, California 92093, USA.
Genes Dev. 2017 Jul 1;31(13):1289-1301. doi: 10.1101/gad.303149.117.
The signals that direct the initiation of transcription ultimately converge at the core promoter, which is the gateway to transcription. Here we provide an overview of the RNA polymerase II core promoter in bilateria (bilaterally symmetric animals). The core promoter is diverse in terms of its composition and function yet is also punctilious, as it acts with strict rules and precision. We additionally describe an expanded view of the core promoter that comprises the classical DNA sequence motifs, sequence-specific DNA-binding transcription factors, chromatin signals, and DNA structure. This model may eventually lead to a more unified conceptual understanding of the core promoter.
指导转录起始的信号最终汇聚于核心启动子，核心启动子是转录的入口。在此，我们概述两侧对称动物（双侧对称动物）中的RNA聚合酶II核心启动子。核心启动子在组成和功能方面具有多样性，但也一丝不苟，因为它严格按照规则精确发挥作用。我们还描述了一种对核心启动子的扩展观点，该观点包括经典的DNA序列基序、序列特异性DNA结合转录因子、染色质信号和DNA结构。这种模型最终可能会带来对核心启动子更统一的概念理解。
