非传统肌球蛋白将肌原纤维插入肌节。
Unconventional myosins muscle into myofibrils.
机构信息
From the Division of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655
出版信息
J Biol Chem. 2019 May 3;294(18):7219-7220. doi: 10.1074/jbc.H119.008784.
Abstract
"Myosin" is famous as a component of muscle fibrils, but the majority of myosin family members act elsewhere with roles unrelated to muscle contraction. The biological functions of a relatively new family of these unconventional myosins, myosins 18A and 18B, are poorly understood. New research from Horsthemke describes a new isoform (Myo18Aγ) that is essential for heart function and viability in mice. Their findings both support and contradict other work in the field and raise new questions about the roles of myosin 18 proteins .
摘要
肌球蛋白”作为肌纤维的组成部分而闻名，但肌球蛋白家族的大多数成员在其他地方发挥作用，与肌肉收缩无关。这些非传统肌球蛋白的一个相对较新的家族，肌球蛋白 18A 和 18B 的生物学功能知之甚少。Horsthemke 的新研究描述了一种新的同工型（Myo18Aγ），它对小鼠的心脏功能和生存能力至关重要。他们的发现既支持又反驳了该领域的其他工作，并提出了关于肌球蛋白 18 蛋白作用的新问题。
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