• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Imaging of CAR T-Cells in Cancer Patients: Paving the Way to Treatment Monitoring and Outcome Prediction.癌症患者中CAR T细胞的成像：为治疗监测和结果预测铺平道路。
J Nucl Med. 2019 Jul;60(7):879-881. doi: 10.2967/jnumed.119.227561. Epub 2019 May 3.
2
Chimeric Antigen Receptor (CAR) T-Cell Therapy.嵌合抗原受体（CAR）T细胞疗法
JAMA Oncol. 2017 Nov 1;3(11):1595. doi: 10.1001/jamaoncol.2017.2989.
3
Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy.用于癌症治疗的多抗原靶向嵌合抗原受体 T 细胞。
J Hematol Oncol. 2019 Nov 29;12(1):128. doi: 10.1186/s13045-019-0813-7.
4
Engineering CAR-T Cells for Next-Generation Cancer Therapy.工程化 CAR-T 细胞用于下一代癌症治疗。
Cancer Cell. 2020 Oct 12;38(4):473-488. doi: 10.1016/j.ccell.2020.07.005. Epub 2020 Jul 30.
5
Companion vaccines for CAR T-cell therapy: applying basic immunology to enhance therapeutic efficacy.嵌合抗原受体（CAR）T细胞疗法的辅助疫苗：应用基础免疫学提高治疗效果
Future Med Chem. 2020 Aug;12(15):1359-1362. doi: 10.4155/fmc-2020-0081. Epub 2020 Jun 29.
6
Chimeric antigen receptor T-cell therapy for cancer: a basic research-oriented perspective.嵌合抗原受体 T 细胞疗法治疗癌症：以基础研究为导向的观点。
Immunotherapy. 2018 Mar;10(3):221-234. doi: 10.2217/imt-2017-0133.
7
CAR T-cell therapy for solid tumours.实体瘤的嵌合抗原受体T细胞疗法
Lancet Oncol. 2021 Jul;22(7):893. doi: 10.1016/S1470-2045(21)00353-3.
8
Radionuclide-based molecular imaging allows CAR-T cellular visualization and therapeutic monitoring.基于放射性核素的分子成像可实现 CAR-T 细胞可视化和治疗监测。
Theranostics. 2021 May 3;11(14):6800-6817. doi: 10.7150/thno.56989. eCollection 2021.
9
Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward.嵌合抗原受体（CAR）T细胞在过继性癌症免疫治疗中的长期持续存在：挑战与未来方向
Front Immunol. 2020 Apr 22;11:702. doi: 10.3389/fimmu.2020.00702. eCollection 2020.
10
Cas13d-mediated gene knockdown in CAR T cells: towards off-the-shelf cancer treatment.Cas13d介导的嵌合抗原受体T细胞基因敲低：迈向现成的癌症治疗方法
Signal Transduct Target Ther. 2024 Apr 26;9(1):113. doi: 10.1038/s41392-024-01830-3.

引用本文的文献

1
CAR-T cell therapy in brain malignancies: obstacles in the face of cellular trafficking and persistence.嵌合抗原受体T细胞疗法在脑恶性肿瘤中的应用：细胞转运与存活面临的障碍
Front Immunol. 2025 Jun 19;16:1596499. doi: 10.3389/fimmu.2025.1596499. eCollection 2025.
2
Development of a DNA Aptamer-Based Approach to Noninvasively Image CAR-T Cells In Vivo and Traceless Enrichment In Vitro.基于DNA适配体的方法用于体内无创成像CAR-T细胞及体外无痕富集的研究进展
Adv Sci (Weinh). 2025 Jul;12(28):e2506746. doi: 10.1002/advs.202506746. Epub 2025 May 11.
3
A Novel Luciferase-Based Reporter Gene Technology for Simultaneous Optical and Radionuclide Imaging of Cells.一种用于细胞光学和放射性核素成像的新型荧光素酶报告基因技术。
Int J Mol Sci. 2024 Jul 27;25(15):8206. doi: 10.3390/ijms25158206.
4
Engineering CAR-T cells for radiohapten capture in imaging and radioimmunotherapy applications.工程化 CAR-T 细胞用于放射性半抗原捕获在成像和放射性免疫治疗应用中。
Theranostics. 2023 Oct 8;13(15):5469-5482. doi: 10.7150/thno.87489. eCollection 2023.
5
Probing immune infiltration dynamics in cancer by in vivo imaging.通过体内成像技术探测癌症中的免疫浸润动态。
Curr Opin Chem Biol. 2022 Apr;67:102117. doi: 10.1016/j.cbpa.2022.102117. Epub 2022 Feb 23.
6
Highly aminated iron oxide nanoworms for simultaneous manufacturing and labeling of chimeric antigen receptor T cells.用于同时制造和标记嵌合抗原受体T细胞的高胺化氧化铁纳米蠕虫
J Magn Magn Mater. 2022 Jan 1;541. doi: 10.1016/j.jmmm.2021.168480. Epub 2021 Aug 29.
7
Early toxicity and clinical outcomes after chimeric antigen receptor T-cell (CAR-T) therapy for lymphoma.嵌合抗原受体 T 细胞（CAR-T）治疗淋巴瘤的早期毒性和临床结局。
J Immunother Cancer. 2021 Aug;9(8). doi: 10.1136/jitc-2020-002303.
8
Pharmacokinetic and pharmacodynamic studies of CD19 CAR T cell in human leukaemic xenograft models with dual-modality imaging.双模式影像示踪的人源白血病异种移植模型中 CD19 CAR T 细胞的药代动力学和药效学研究。
J Cell Mol Med. 2021 Aug;25(15):7451-7461. doi: 10.1111/jcmm.16776. Epub 2021 Jul 9.
9
Current and Future Role of Medical Imaging in Guiding the Management of Patients With Relapsed and Refractory Non-Hodgkin Lymphoma Treated With CAR T-Cell Therapy.医学成像在指导接受CAR T细胞疗法治疗的复发难治性非霍奇金淋巴瘤患者管理中的当前及未来作用
Front Oncol. 2021 May 28;11:664688. doi: 10.3389/fonc.2021.664688. eCollection 2021.
10
Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy.代谢放射性标记和细胞毒性 T 淋巴细胞的体内 PET 成像指导组合过继细胞转移癌症治疗。
J Nanobiotechnology. 2021 Jun 10;19(1):175. doi: 10.1186/s12951-021-00924-2.

本文引用的文献

1
Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer.Zr-atezolizumab 成像作为一种非侵入性方法，用于评估 PD-L1 阻断在癌症中的临床反应。
Nat Med. 2018 Dec;24(12):1852-1858. doi: 10.1038/s41591-018-0255-8. Epub 2018 Nov 26.
2
Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo.CAR-T 细胞靶向递送 PD-1 阻断 scFv 增强体内抗肿瘤疗效。
Nat Biotechnol. 2018 Oct;36(9):847-856. doi: 10.1038/nbt.4195. Epub 2018 Aug 13.
3
Non-invasive visualization of tumor infiltrating lymphocytes in patients with metastatic melanoma undergoing immune checkpoint inhibitor therapy: a pilot study.转移性黑色素瘤患者接受免疫检查点抑制剂治疗时肿瘤浸润淋巴细胞的无创可视化：一项初步研究。
Oncotarget. 2018 Jul 13;9(54):30268-30278. doi: 10.18632/oncotarget.25666.
4
Antibody with Infinite Affinity for In Vivo Tracking of Genetically Engineered Lymphocytes.具有无限亲和力的抗体，用于体内追踪基因工程化淋巴细胞。
J Nucl Med. 2018 Dec;59(12):1894-1900. doi: 10.2967/jnumed.118.208041. Epub 2018 Jun 14.
5
Imaging T Cell Dynamics and Function Using PET and Human Nuclear Reporter Genes.利用正电子发射断层扫描（PET）和人类核报告基因成像T细胞动力学与功能
Methods Mol Biol. 2018;1790:165-180. doi: 10.1007/978-1-4939-7860-1_13.
6
Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells.嵌合抗原受体T细胞的临床合规时空成像
Nat Commun. 2018 Mar 14;9(1):1081. doi: 10.1038/s41467-018-03524-1.
7
A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant.一种用于可视化同种异体造血细胞移植引发的急性移植物抗宿主病中活化T细胞的正电子发射断层显像（PET）成像策略。
Cancer Res. 2017 Jun 1;77(11):2893-2902. doi: 10.1158/0008-5472.CAN-16-2953.
8
Chimeric Antigen Receptors: A Cell and Gene Therapy Perspective.嵌合抗原受体：细胞与基因治疗视角
Mol Ther. 2017 May 3;25(5):1117-1124. doi: 10.1016/j.ymthe.2017.03.034. Epub 2017 Apr 26.
9
Advancing Immune and Cell-Based Therapies Through Imaging.通过成像推进免疫和基于细胞的疗法。
Mol Imaging Biol. 2017 Jun;19(3):379-384. doi: 10.1007/s11307-017-1069-7.
10
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.利用CRISPR/Cas9将嵌合抗原受体（CAR）靶向至T细胞受体α恒定区（TRAC）基因座可增强肿瘤排斥反应。
Nature. 2017 Mar 2;543(7643):113-117. doi: 10.1038/nature21405. Epub 2017 Feb 22.

Imaging of CAR T-Cells in Cancer Patients: Paving the Way to Treatment Monitoring and Outcome Prediction.

作者信息

Krebs Simone, Ponomarev Vladimir, Slovin Susan, Schöder Heiko

机构信息

Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.

Radiochemistry and Molecular Imaging Sciences Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; and.

出版信息

J Nucl Med. 2019 Jul;60(7):879-881. doi: 10.2967/jnumed.119.227561. Epub 2019 May 3.

DOI:10.2967/jnumed.119.227561
PMID:31053682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12079154/
Abstract
摘要