Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University, Chicago, IL, USA; Department of Dermatology, Beth Israel Medical Center and St. Luke's-Roosevelt Hospital Center, New York, NY, USA.
Allergy. 2014 Jan;69(1):95-103. doi: 10.1111/all.12319. Epub 2013 Nov 20.
Previous studies using animal models suggest an association between allergic disease and epilepsy. We sought to determine whether allergic disease is associated with epilepsy in children.
We used the 2007-2008 National Survey of Children's Health, a US population-based study of 91 642 children aged 0-17 years to determine the association between the prevalence of epilepsy and allergic disease, including asthma, atopic dermatitis (AD)/eczema, hay fever, and food allergies. Multivariate logistic regression models were constructed that controlled for confounding variables.
The US lifetime prevalence of childhood epilepsy was 1.03% and was significantly associated with older age, male sex, lower household income, family structure and history of brain injury or concussion. Children with ≥1 allergic disease had more epilepsy in their lifetime than nonallergic children (logistic regression, adjusted odds ratio [95% confidence interval] = 1.79 [1.37-2.33]). Lifetime prevalence (2.30 [1.50-3.52]) and one-year prevalence of asthma (2.00 [1.41-2.84]), AD/eczema (1.73 [1.17-2.56]), hay fever (1.93 [1.41-2.65]) and food allergies (2.69 [1.38-4.01]) were associated with increased odds of ever being diagnosed with epilepsy. Similar results were found for current history of epilepsy. Severe AD/eczema (3.89 [1.34-11.32]) [corrected] and hay fever (2.46 [1.11-5.41]) were associated with even higher odds of epilepsy compared with mild/moderate disease. As the number of allergic diseases increased, so did the odds of lifetime history and current history of epilepsy.
The US prevalence of epilepsy is associated with allergic diseases in children. Further studies are needed to determine whether allergic inflammation contributes toward epileptogenesis.
先前的动物模型研究表明，过敏疾病与癫痫之间存在关联。我们旨在确定过敏疾病是否与儿童癫痫有关。
我们使用了 2007-2008 年全国儿童健康调查，这是一项针对 91642 名 0-17 岁儿童的基于人群的美国研究，以确定癫痫与过敏疾病（包括哮喘、特应性皮炎/湿疹、花粉热和食物过敏）的患病率之间的关联。构建了多变量逻辑回归模型，以控制混杂变量。
美国儿童癫痫的终生患病率为 1.03%，与年龄较大、男性、较低的家庭收入、家庭结构以及脑损伤或脑震荡的病史有关。患有≥1 种过敏疾病的儿童一生中患癫痫的可能性高于非过敏儿童（逻辑回归，调整后的优势比[95%置信区间]=1.79[1.37-2.33]）。终生患病率（2.30[1.50-3.52]）和哮喘的一年患病率（2.00[1.41-2.84]）、特应性皮炎/湿疹（1.73[1.17-2.56]）、花粉热（1.93[1.41-2.65]）和食物过敏（2.69[1.38-4.01]）与癫痫的诊断几率增加有关。对于当前癫痫病史，也有类似的结果。严重的特应性皮炎/湿疹（3.89[1.34-11.32]）[校正]和花粉热（2.46[1.11-5.41]）与轻度/中度疾病相比，癫痫的几率更高。随着过敏疾病数量的增加，终生和当前癫痫病史的几率也随之增加。
美国癫痫的患病率与儿童过敏疾病有关。需要进一步的研究来确定过敏炎症是否有助于癫痫发生。
