Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, University of British Columbia, Vancouver, Canada.
Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research Institute, British Columbia, Canada.
J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):755-763. doi: 10.1093/gerona/glz115.
BACKGROUND: Aging is characterized by cognitive changes in specific domains, such as declines in memory and executive functions. Given the world's aging population, it is important to identify and evaluate strategies that promote healthy cognitive aging. Besides exercise, computerized cognitive training (CCT) is a promising approach to promote cognitive function. Moreover, a single bout of exercise immediately prior to CCT may provide additional cognitive benefits. METHODS: An 8-week proof-of-concept randomized controlled trial to investigate the effect of a commercial CCT intervention, alone and when preceded by exercise, on cognitive function. Participants (124; aged 65-85 years) performed 8 weeks of: (i) Group-based CCT (Fit Brains) 3×/week for 1 hour plus 3×/week home-based training; (ii) Group-based CCT preceded by exercise (Ex-CCT) 3×/week for 1 hour plus 3×/week home-based training (exercise+CCT); or (iii) Group-based balanced and toned (BAT) classes 3×/week for 1 hour (control). Memory was assessed by the Rey Auditory Verbal Learning Test. Executive functions were assessed using the: (i) Stroop Test, (ii) Trail Making Tests (TMT), (iii) Flanker Test, and (iv) Dimensional Change Card Sort Test (DCCS). RESULTS: At trial completion, there were no significant between-group differences in memory (p > .05). However, compared with BAT, CCT, and Ex-CCT significantly improved Stroop performance (-10.72, 95% confidence interval [CI]: -16.53, -4.91; -7.95, 95% CI: -13.77, -2.13, respectively). Moreover, Ex-CCT significantly improved the performance on TMT (-13.65, 95% CI: -26.09, -1.22), the Flanker Test (6.72, 95% CI: 2.55, 10.88), and the DCCS Test (6.75, 95% CI: 0.99, 12.50). CONCLUSION: An 8-week CCT program may promote executive functions in older adults and combining it with a bout of exercise may provide broader benefits.
背景：衰老的特征是特定领域的认知变化，例如记忆和执行功能下降。鉴于世界人口老龄化，识别和评估促进健康认知衰老的策略非常重要。除了运动，计算机化认知训练（CCT）是促进认知功能的一种很有前途的方法。此外，在 CCT 之前进行单次运动可能会提供额外的认知益处。
方法：一项为期 8 周的概念验证随机对照试验，旨在调查单独进行和在运动前进行商业 CCT 干预对认知功能的影响。参与者（124 人；年龄 65-85 岁）进行了 8 周的以下治疗：（i）基于小组的 CCT（Fit Brains）每周 3 次，每次 1 小时，外加每周 3 次的家庭训练；（ii）基于小组的 CCT 前进行运动（Ex-CCT）每周 3 次，每次 1 小时，外加每周 3 次的家庭训练（运动+CCT）；或（iii）基于小组的平衡和调和（BAT）课程每周 3 次，每次 1 小时（对照组）。记忆通过 Rey 听觉言语学习测试进行评估。执行功能使用以下测试进行评估：（i）Stroop 测试，（ii）Trail Making Tests（TMT），（iii）Flanker 测试和（iv）维度变化卡片分类测试（DCCS）。
结果：在试验完成时，各组之间的记忆没有明显差异（p>.05）。然而，与 BAT 相比，CCT 和 Ex-CCT 显著改善了 Stroop 表现（-10.72，95%置信区间[CI]：-16.53，-4.91；-7.95，95% CI：-13.77，-2.13，分别）。此外，Ex-CCT 显著改善了 TMT（-13.65，95% CI：-26.09，-1.22）、Flanker 测试（6.72，95% CI：2.55，10.88）和 DCCS 测试（6.75，95% CI：0.99，12.50）的表现。
结论：为期 8 周的 CCT 计划可能会促进老年人的执行功能，并且将其与一次运动相结合可能会带来更广泛的益处。
J Int Neuropsychol Soc. 2024-5
Sensors (Basel). 2025-3-26
Healthcare (Basel). 2023-11-22
Zotero 插件