8 周计算机化认知训练对老年人的影响：一项随机对照试验的研究方案。
The effects of an 8-week computerized cognitive training program in older adults: a study protocol for a randomized controlled trial.
机构信息
Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, Djavad Mowafaghian Centre for Brain Health, Centre for Hip Health and Mobility, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
出版信息
BMC Geriatr. 2018 Jan 30;18(1):31. doi: 10.1186/s12877-018-0730-6.
BACKGROUND
Given the world's aging population, it is important to identify strategies that promote healthy cognitive aging and minimize cognitive decline. Currently, no curative pharmaceutical therapy exists for cognitive impairment and dementia. As a result, there is much interest in lifestyle approaches. Specifically, complex mental activity, such as cognitive training, may be a promising method to combat cognitive decline in older adults. As such, the industry of commercial computerized cognitive training (CCT) applications has rapidly grown in the last decade. However, the efficacy of these commercial products is largely not established. Moreover, exercise is a recognized strategy for promoting cognitive outcomes in older adults and may augment the efficacy of computerized cognitive training applications. Therefore, we propose a proof-of-concept randomized controlled trial (RCT) to examine the effect of a commercial CCT program in community-dwelling older adults.
METHODS
An 8-week RCT to examine the effect of a commercial CCT program, alone and preceded by a 15-min brisk walk, on cognitive function and explore the underlying neural mechanisms in adults aged 65-85 years old. Participants will be randomized to one of three intervention groups: 1) Computerized cognitive training (FBT); 2) A 15-min brisk walk followed by computerized cognitive training (Ex-FBT); or 3) A combination of educational classes, sham cognitive training, and balanced and tone exercises (active control, BAT). Participants in all intervention groups will attend three one-hour classes per week over the course of the intervention. Participants will be assessed at baseline, trial completion, and 1-year post study completion (1-year follow-up).
DISCUSSION
If results from this study show benefits for cognition at trial completion, CCT programs, alone or in combination with walking, might be a strategy to promote healthy cognitive aging in older adults. In addition, results from the 1-year follow-up measurement could provide important information regarding the long-term benefits of these CCT programs.
TRIAL REGISTRATION
ClinicalTrials.gov Protocol Registration System: NCT02564809; registered September 1, 2015.
背景
鉴于世界人口老龄化，确定促进健康认知老化和最小化认知能力下降的策略非常重要。目前，尚无针对认知障碍和痴呆的治愈性药物治疗方法。因此，人们对生活方式方法产生了浓厚的兴趣。具体来说，复杂的脑力活动，如认知训练，可能是对抗老年人认知能力下降的一种很有前途的方法。因此，在过去十年中，商业化的计算机认知训练（CCT）应用程序行业迅速发展。然而，这些商业产品的疗效在很大程度上尚未得到证实。此外，运动是促进老年人认知结果的公认策略，并且可能增强计算机认知训练应用程序的效果。因此，我们提出了一项概念验证随机对照试验（RCT），以检查商业化 CCT 计划对社区居住的老年人认知功能的影响，并探索其潜在的神经机制。
方法
一项 8 周 RCT，旨在检查商业化 CCT 计划（单独使用或在 15 分钟快走后使用）对 65-85 岁成年人认知功能的影响，并探索其潜在的神经机制。参与者将随机分为三组干预组之一：1）计算机认知训练（FBT）；2）15 分钟快走后进行计算机认知训练（Ex-FBT）；或 3）结合教育课程、假认知训练以及平衡和音调练习（主动对照，BAT）。所有干预组的参与者将在干预期间每周参加三次为期一小时的课程。参与者将在基线、试验完成时和研究完成后 1 年（1 年随访）进行评估。
讨论
如果本研究在试验完成时显示对认知有获益，那么 CCT 计划（单独或与步行结合使用）可能是促进老年人健康认知老化的一种策略。此外，1 年随访测量的结果可以提供有关这些 CCT 计划的长期获益的重要信息。
试验注册
ClinicalTrials.gov 协议注册系统：NCT02564809；注册日期：2015 年 9 月 1 日。
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