β-内酰胺类抗生素亚抑菌浓度诱导的淋病奈瑟菌肽聚糖改变
Alterations in peptidoglycan of Neisseria gonorrhoeae induced by sub-MICs of beta-lactam antibiotics.
作者信息
Garcia-Bustos J F, Dougherty T J
出版信息
Antimicrob Agents Chemother. 1987 Feb;31(2):178-82. doi: 10.1128/AAC.31.2.178.
Abstract
Exposure of Neisseria gonorrhoeae to sub-MICs of selected beta-lactam antibiotics caused distortion of normal cell morphology. Analysis of the peptidoglycan indicated that the cells were accumulating increased quantities of disaccharide pentapeptide in their cell walls. The O-acetylated form of the disaccharide pentapeptide was not detected among the major peaks. The correlation of antibiotic binding to gonococcal penicillin-binding protein 2 and accumulation of non-O-acetylated disaccharide pentapeptide suggested an explanation for the previously observed relationship of penicillin-binding protein 2 and O-acetylation of peptidoglycan.
摘要
淋病奈瑟菌暴露于选定β-内酰胺抗生素的亚抑菌浓度会导致正常细胞形态扭曲。对肽聚糖的分析表明，细胞在其细胞壁中积累了数量增加的二糖五肽。在主要峰中未检测到二糖五肽的O-乙酰化形式。抗生素与淋球菌青霉素结合蛋白2的结合以及非O-乙酰化二糖五肽的积累之间的相关性，为先前观察到的青霉素结合蛋白2与肽聚糖O-乙酰化之间的关系提供了解释。
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