大肠杆菌中寡聚胞壁质中间体的缺失
Absence of oligomeric murein intermediates in Escherichia coli.
作者信息
Goodell E W, Markiewicz Z, Schwarz U
出版信息
J Bacteriol. 1983 Oct;156(1):130-5. doi: 10.1128/jb.156.1.130-135.1983.
Abstract
The intermediates in the biosynthetic pathway of murein were examined in two strains of Escherichia coli to determine whether they synthesized oligomeric precursors in vivo. No oligomeric precursors could be detected; the only intermediates found were the previously described UDP-N-acetylmuramyl peptides, and the two lipid-linked compounds, N-acetylglucosamyl-N-acetylmuramyl-(pentapeptide)-pyrophosphoryl-undecaprenol and N-acetylmuramyl-(pentapeptide)-pyrophosphoryl-undecaprenol. It was concluded that lipid-linked monomers are directly incorporated into the murein sacculus in vivo and do not pass through an oligomeric stage.
摘要
对两株大肠杆菌中胞壁质生物合成途径的中间体进行了检测，以确定它们在体内是否合成寡聚前体。未检测到寡聚前体；发现的唯一中间体是先前描述的UDP-N-乙酰胞壁酰肽，以及两种脂质连接化合物，N-乙酰葡糖胺-N-乙酰胞壁酰-（五肽）-焦磷酸十一异戊烯醇和N-乙酰胞壁酰-（五肽）-焦磷酸十一异戊烯醇。得出的结论是，脂质连接的单体在体内直接掺入胞壁质囊泡中，不经过寡聚阶段。
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