Delft University of Technology, Department of Biotechnology, van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Delft University of Technology, Department of Biotechnology, van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Trends Biotechnol. 2019 Oct;37(10):1042-1050. doi: 10.1016/j.tibtech.2019.04.002. Epub 2019 May 1.
Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous mathematical descriptions of microbial cells and consortia thereof will enable deeper biological understanding and lead to powerful in silico cellular models. Biological engineering, namely model-based design together with synthetic biology, will accelerate the construction of robust and high-performing microorganisms. Using these organisms, and ambitions towards zero-concepts with respect to emissions and excess resources in bioprocess engineering, industrial biotechnology is expected to become highly integrated into sustainable generations of technology systems.
未来的制造业将专注于新产品和改进产品，以及新的和增强的生产方法。最近的生物技术和科学进步，如 CRISPR/Cas 和各种组学技术，为令人兴奋的新型生物技术研究、开发和商业化新的可持续产品铺平了道路。对微生物细胞及其群落的严格数学描述将使人们能够更深入地了解生物学，并导致强大的计算机细胞模型。生物工程，即基于模型的设计与合成生物学的结合，将加速构建稳健和高性能的微生物。利用这些生物体，以及在生物过程工程中实现零排放和零资源过剩的目标，工业生物技术有望高度融入可持续发展的技术系统。
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