Department of Paediatric Surgery and Organ Transplantation, Children's Memorial Health Institute, Warsaw, Poland.
Department of Paediatric Surgery and Organ Transplantation, Children's Memorial Health Institute, Warsaw, Poland.
J Hosp Infect. 2019 Oct;103(2):223-226. doi: 10.1016/j.jhin.2019.04.022. Epub 2019 May 2.
Central venous access poses a risk for the development of catheter-related infections (CRIs). The aim of this study was to evaluate prophylactic use of taurolidine-citrate (T-C) solution on the number of CRIs. Ninety-seven catheters, used in 86 children, were divided at random into two groups: Group T(-) (N=49) underwent standard aseptic procedures, and Group T(+) (N=48) received additional filling of the lines with T-C solution during intervals in cycles of parenteral nutrition or drug supply. Sixteen CRIs occurred in Group T(-) and one CRI occurred in Group T(+); this difference was significant (P<0.05). Use of T-C appears to be a safe and effective method for the prevention of CRIs.
中心静脉置管有发生导管相关性感染（CRI）的风险。本研究旨在评估牛磺罗定-柠檬酸盐（T-C）溶液在预防 CRI 方面的作用。97 根导管在 86 名儿童中随机分为两组：T(-)组（N=49）采用标准无菌操作，T(+)组（N=48）在接受肠外营养或药物供应周期的间歇期间，额外向导管内注入 T-C 溶液。T(-)组发生 16 例 CRI，T(+)组发生 1 例 CRI，差异有统计学意义（P<0.05）。T-C 的使用似乎是预防 CRI 的一种安全有效的方法。
