School of Chemistry and Chemical Engineering, Shihezi University/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan/Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region/Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bingtuan, Shihezi, Xinjiang, 832003, PR China.
School of Medicine, Shihezi University, Shihezi, 832002, Xinjiang, PR China.
Colloids Surf B Biointerfaces. 2019 Aug 1;180:237-244. doi: 10.1016/j.colsurfb.2019.04.043. Epub 2019 Apr 27.
A novel antibacterial hydrogel was prepared through the addition of IT to a chitin (CT) and polyvinyl alcohol (PVA) hydrogel, creating a promising material for wound dressings. The addition of nano particles IT endowed the anti-bacterial activity of hydrogel as well as had a positive impact on the mechanical properties of the hydrogels. The structure of the prepared hydrogel dressing was characterized by FTIR, XPS, XRD, SEM and TEM. The composite hydrogel exhibited excellent anti-bacterial activity under the visible light. Cytotoxicity tests (L929 fibroblast cells) showed all samples achieving up to 80% cell viability. Furthermore, compared with conventional dressings, wound healing test revealed that CT/PVA/IT hydrogel could accelerated wound healing in vivo, wound closure rates reached 95.5% after 10 days. This study suggests that the novel hydrogel has considerable potential for applications in wound dressings.
一种新型抗菌水凝胶通过将 IT 添加到壳聚糖 (CT) 和聚乙烯醇 (PVA) 水凝胶中制备而成，为伤口敷料创造了一种有前途的材料。纳米粒子 IT 的添加赋予了水凝胶抗菌活性，同时对水凝胶的机械性能产生了积极影响。通过傅里叶变换红外光谱 (FTIR)、X 射线光电子能谱 (XPS)、X 射线衍射 (XRD)、扫描电子显微镜 (SEM) 和透射电子显微镜 (TEM) 对制备的水凝胶敷料的结构进行了表征。复合水凝胶在可见光下表现出优异的抗菌活性。细胞毒性试验（L929 成纤维细胞）表明所有样品的细胞活力均达到 80%。此外，与传统敷料相比，伤口愈合试验表明 CT/PVA/IT 水凝胶在体内可加速伤口愈合，10 天后伤口闭合率达到 95.5%。本研究表明，新型水凝胶在伤口敷料方面具有相当大的应用潜力。
