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科威特多发性硬化症的患病率持续上升。

The prevalence of multiple sclerosis continues to increase in Kuwait.

机构信息

Division of Neurology, Department of Medicine, Amiri Hospital, Arabian Gulf Street, Sharq, 11013, Kuwait.

Faculty of Medicine, Kuwait University, Kuwait.

出版信息

Mult Scler Relat Disord. 2019 Jul;32:74-76. doi: 10.1016/j.msard.2019.04.033. Epub 2019 Apr 29.

DOI:10.1016/j.msard.2019.04.033
PMID:31055174
Abstract

BACKGROUND

The national MS registry was established in 2010 to assess the change in epidemiological status. The last reported data of the prevalence and incidence in Kuwait was in 2013.

OBJECTIVES

To update the prevalence and incidence rates of MS among Kuwaiti nationals.

METHODS

Using the national MS registry, a cross sectional study was conducted to estimate the number of all patients diagnosed with MS and clinically isolated syndrome suggestive of MS. The diagnosis was based on the revised 2017 McDonald criteria. The population census was acquired from the Public Authority of Civil Information.

RESULTS

On 30th June 2018, 1454 Kuwaiti MS patients fulfilled the diagnostic criteria. Women represented 66.8% of the analyzed cohort with female to male ratio of 2.01:1. The crude prevalence of MS was 104.88 (95% CI: 89.5-121.9) per 100,000 persons, which increased 1.6 times since 2013. Age-adjusted prevalence peaked in the 30-39 and 40-49 year age groups in both females and male, with a decreasing tendency beyond 50 years of age. The incidence of MS was 5.39 (95% CI: 4.3-6.8) per 100,000 persons. The 5-year incidence was 6.4 per 100,000, which has been stable since the last reported rate.

CONCLUSION

The prevalence of MS in Kuwaiti nationals continued to increase reflecting a better case ascertainment and improved awareness and referrals across the country. However, the incidence has stabilized in the last 5 years which was mostly driven by a slight decline in newly diagnosed cases in women compared to men despite the increase in the overall female to male ratio.

摘要

背景

国家多发性硬化症注册中心成立于 2010 年,旨在评估流行病学状况的变化。科威特最后一次报告的患病率和发病率数据是在 2013 年。

目的

更新科威特国民多发性硬化症的患病率和发病率。

方法

利用国家多发性硬化症注册中心,进行了一项横断面研究,以估计所有被诊断为多发性硬化症和疑似多发性硬化症的临床孤立综合征的患者人数。诊断基于修订后的 2017 年麦当劳标准。人口普查数据来自公共信息管理局。

结果

截至 2018 年 6 月 30 日,有 1454 名科威特多发性硬化症患者符合诊断标准。女性占分析队列的 66.8%,女性与男性的比例为 2.01:1。多发性硬化症的粗患病率为 104.88(95%CI:89.5-121.9)/10 万人,比 2013 年增加了 1.6 倍。年龄调整后的患病率在女性和男性的 30-39 岁和 40-49 岁年龄组中达到峰值,超过 50 岁后呈下降趋势。多发性硬化症的发病率为 5.39(95%CI:4.3-6.8)/10 万人。5 年发病率为 6.4/10 万人,自上次报告以来一直保持稳定。

结论

科威特国民多发性硬化症的患病率继续上升,反映出全国范围内病例发现、意识和转诊的改善。然而,发病率在过去 5 年中稳定下来,这主要是由于与男性相比,女性新诊断病例略有下降,尽管整体女性与男性的比例有所增加。

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