Akhtar Saeed, Alroughani Raed
Department of Community Medicine and Behavioural Sciences, Faculty of Medicine, University of Kuwait, PO Box 24923, Safat, 13110, Kuwait.
Department of Medicine, Division of Neurology, Amiri Hospital, Arabian Gulf Street, Sharq 11013, Kuwait.
Mult Scler Relat Disord. 2021 Jan;47:102676. doi: 10.1016/j.msard.2020.102676. Epub 2020 Dec 6.
This cross-sectional cohort study quantified the disparities in MS risk by age, sex, nativity from 1980 to 2019 in Kuwait.
Age-standardized MS incidence rate (ASIR) (per 100,000 person-years) overall and by subcohorts defined by cross-classification of the period (5-year groups) of diagnosis, age at onset, sex (female or male) and nativity (Kuwaiti or non-Kuwaiti) were computed and analyzed using multivariable negative binomial model.
Overall MS ASIR (per 100,000 person-years) was 3.41 (95% CI: 1.61, 5.21), which exponentially increased from 1980 to 2014 before drifting downward in 2015-2019 period. Compared with adults (age ≥ 40 years), males, non-Kuwaiti residents respectively, young adults (20-39 years), females and Kuwaiti nationals were significantly (p < 0.05) more likely to develop MS after adjusting for the period effect.
A high overall MS ASIR (per 100,000 person-years) was recorded with substantial temporal variation between 1980 and 2019. Young adults (20-39 years), females and Kuwaiti nationals constituted MS high-risk groups. The knowledge of underlying interface pathways between genetic and environmental factors may provide insights into MS pathogenesis and leads for future research.
这项横断面队列研究对1980年至2019年科威特按年龄、性别、出生地划分的多发性硬化症（MS）风险差异进行了量化。
计算并使用多变量负二项式模型分析总体以及按诊断时期（5年组）、发病年龄、性别（女性或男性）和出生地（科威特人或非科威特人）交叉分类定义的亚队列的年龄标准化MS发病率（ASIR）（每10万人年）。
总体MS ASIR（每10万人年）为3.41（95%CI：1.61，5.21），在1980年至2014年呈指数增长，在2015 - 2019年期间有所下降。在调整时期效应后，与成年人（年龄≥40岁）、男性、非科威特居民相比，年轻人（20 - 39岁）、女性和科威特国民患MS的可能性显著更高（p < 0.05）。
记录到较高的总体MS ASIR（每10万人年），1980年至2019年期间存在显著的时间变化。年轻人（20 - 39岁）、女性和科威特国民构成MS高危人群。了解遗传和环境因素之间潜在的相互作用途径可能为MS发病机制提供见解，并为未来研究指明方向。
