不同禁食时间段对下丘脑外侧区5-羟色胺合成的影响。

Effects of various periods of food deprivation on serotonin synthesis in the lateral hypothalamus.

作者信息

Kantak K M, Wayner M J, Stein J M

出版信息

Pharmacol Biochem Behav. 1978 Oct;9(4):535-41. doi: 10.1016/0091-3057(78)90055-2.

Abstract

One hr following an infusion of 3H-L-tryptophan, the lateral hypothalamus was perfused with physiological bacteriostatic saline for 40 min. Samples of perfusate, which corresponded to 75--90 min post-infusion, were analyzed by thin layer chromatography for estimation of 3H-labelled L-tryptophan, 5-hydroxytryptophan and 5-hydroxytryptamine. The results indicate that tryptophan uptake and serotonin synthesis are enhanced as a function of hours of food deprivation.

摘要

输注3H-L-色氨酸1小时后，用生理抑菌盐水灌注下丘脑外侧40分钟。对输注后75 - 90分钟的灌注液样本进行薄层色谱分析，以估算3H标记的L-色氨酸、5-羟色氨酸和5-羟色胺。结果表明，色氨酸摄取和5-羟色胺合成随禁食时间的延长而增强。