丙咪嗪对下丘脑外侧5-羟色胺代谢的影响。

Effect of imipramine on serotonin turnover in the lateral hypothalamus.

作者信息

Kantak K M, Wayner M J, Stein J M, Tilson H A

出版信息

Pharmacol Biochem Behav. 1978 Nov;9(5):693-6. doi: 10.1016/0091-3057(78)90223-x.

Abstract

One hour following an infusion of 3H-5-hydroxytryptamine, animals were injected with either 15 mg/kg imipramine hydrochloride or 0.9% NaCl and then the lateral hypothalamus was perfused for 40 min. Samples of perfusate were analyzed by thin layer chromatography for estimation of 3H-labelled 5-hydroxytryptamine and metabolites. The results indicate that impramine hydrochloride 15 mg/kg decreases serotonin release and turnover in the lateral hypothalamus.

摘要

在输注3H-5-羟色胺1小时后，给动物注射15mg/kg盐酸丙咪嗪或0.9%氯化钠，然后对下丘脑外侧进行40分钟的灌注。通过薄层色谱法分析灌注液样品，以估计3H标记的5-羟色胺及其代谢产物。结果表明，15mg/kg盐酸丙咪嗪可降低下丘脑外侧的血清素释放和周转率。