[超氧化物歧化酶的抗惊厥作用]
[Anticonvulsive effect of superoxide dismutase].
作者信息
Kryzhanovskiĭ G N, Nikushkin E V, Tupeev I R, Braslavskiĭ V E
出版信息
Biull Eksp Biol Med. 1987 Apr;103(4):396-8.
The influence of superoxide dismutase (SOD) on the development of focal epileptic activity (EpA) in the rat brain cortex has been investigated. Intraperitoneal administration of SOD to rats (1 mg/kg) 30 minutes before penicillin application to the sensorimotor cortex led to marked relaxation of EpA and a decrease in the concentration of lipid peroxidation (LPO) products in EpA focus. The results corroborate our earlier assumption on an important pathogenetic role of LPO disturbances in epileptogenesis and make reasonable the combination of the traditional anticonvulsive therapy with the agents activating the oxidative system.
研究了超氧化物歧化酶（SOD）对大鼠大脑皮层局灶性癫痫活动（EpA）发展的影响。在将青霉素应用于感觉运动皮层前30分钟，给大鼠腹腔注射SOD（1毫克/千克），可使EpA明显缓解，并使EpA病灶中脂质过氧化（LPO）产物的浓度降低。这些结果证实了我们早期关于LPO紊乱在癫痫发生中重要致病作用的假设，并使传统抗惊厥疗法与激活氧化系统的药物联合使用变得合理。
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