Department of Medicine, Emory University, Atlanta, GA, USA.
Semin Diagn Pathol. 2019 May;36(3):182-186. doi: 10.1053/j.semdp.2019.04.011. Epub 2019 Apr 17.
The first reports of carbapenem resistance in Enterobacteriaceae isolates occurred in the early 1990s. Researchers published the first report of an isolate that produced Klebsiella pneumoniae carbapenemase in 2001. Since that time, carbapenemase-producing Enterobacteriaceae isolates have disseminated globally. Microbiology laboratories are integral to the control of carbapenem-resistant Enterobacteriaceae (CRE). Laboratories need to be able to identify CRE, identify possible therapeutic alternatives, and sometimes identify the type of mechanism responsible for the carbapenem-resistant phenotype. Knowledge of these tasks is essential for all clinical microbiology laboratorians.
肠杆菌科分离株碳青霉烯类耐药的首次报道出现在 20 世纪 90 年代初。研究人员在 2001 年发表了首例产生肺炎克雷伯菌碳青霉烯酶的分离株的报告。自那时以来，产碳青霉烯酶肠杆菌科分离株已在全球传播。微生物学实验室是控制碳青霉烯类耐药肠杆菌科（CRE）的重要组成部分。实验室需要能够鉴定 CRE、鉴定可能的治疗替代药物，有时还需要鉴定导致碳青霉烯类耐药表型的机制类型。所有临床微生物学实验室人员都必须了解这些任务。
