B7-H3 共刺激分子在慢性单纯性苔藓中的异常表达与朗格汉斯细胞的扩增有关。
Abnormal expression of the co-stimulatory molecule B7-H3 in lichen simplex chronicus is associated with expansion of Langerhans cells.
机构信息
Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Clin Exp Dermatol. 2020 Jan;45(1):30-35. doi: 10.1111/ced.14001. Epub 2019 Jul 3.
BACKGROUND
The co-stimulatory molecule B7-H3, a cell surface transmembrane glycoprotein, was assessed for its functional and prognostic role in lichen simplex chronicus (LSC).
AIM
To investigate if abnormal expression of the co-stimulatory molecule B7-H3 in LSC is associated with Langerhans cell (LC) expansion.
METHODS
We used immunohistochemistry to stain LSC skin tissue, and evaluated if the immunostaining of B7-H3 and interleukin (IL)-6 was significantly different.
RESULTS
Our results indicated that B7-H3 is abnormally expressed in LSC skin tissue and positively regulates LC expansion. We also found that IL-6 might modulate B7-H3 expression. Moreover, LC expansion in LSC leads to the proliferation of T cells.
CONCLUSIONS
Our study indicates the potential value of immunotherapy as a treatment for LSC.
背景
共刺激分子 B7-H3 是一种细胞表面跨膜糖蛋白，其在慢性单纯性苔藓（LSC）中的功能和预后作用已被评估。
目的
研究共刺激分子 B7-H3 在 LSC 中的异常表达是否与朗格汉斯细胞（LC）扩增有关。
方法
我们使用免疫组织化学染色 LSC 皮肤组织，并评估 B7-H3 和白细胞介素（IL）-6 的免疫染色是否存在显著差异。
结果
我们的结果表明，B7-H3 在 LSC 皮肤组织中异常表达，并正向调节 LC 扩增。我们还发现 IL-6 可能调节 B7-H3 的表达。此外，LSC 中的 LC 扩增导致 T 细胞增殖。
结论
我们的研究表明免疫疗法作为 LSC 治疗方法具有潜在价值。
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