Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Clin Exp Dermatol. 2020 Jan;45(1):30-35. doi: 10.1111/ced.14001. Epub 2019 Jul 3.
The co-stimulatory molecule B7-H3, a cell surface transmembrane glycoprotein, was assessed for its functional and prognostic role in lichen simplex chronicus (LSC).
To investigate if abnormal expression of the co-stimulatory molecule B7-H3 in LSC is associated with Langerhans cell (LC) expansion.
We used immunohistochemistry to stain LSC skin tissue, and evaluated if the immunostaining of B7-H3 and interleukin (IL)-6 was significantly different.
Our results indicated that B7-H3 is abnormally expressed in LSC skin tissue and positively regulates LC expansion. We also found that IL-6 might modulate B7-H3 expression. Moreover, LC expansion in LSC leads to the proliferation of T cells.
Our study indicates the potential value of immunotherapy as a treatment for LSC.
共刺激分子 B7-H3 是一种细胞表面跨膜糖蛋白，其在慢性单纯性苔藓（LSC）中的功能和预后作用已被评估。
研究共刺激分子 B7-H3 在 LSC 中的异常表达是否与朗格汉斯细胞（LC）扩增有关。
我们使用免疫组织化学染色 LSC 皮肤组织，并评估 B7-H3 和白细胞介素（IL）-6 的免疫染色是否存在显著差异。
我们的结果表明，B7-H3 在 LSC 皮肤组织中异常表达，并正向调节 LC 扩增。我们还发现 IL-6 可能调节 B7-H3 的表达。此外，LSC 中的 LC 扩增导致 T 细胞增殖。
我们的研究表明免疫疗法作为 LSC 治疗方法具有潜在价值。
