Peng Li, Yu Qianying, Zhang Jie, Mi Xiongfei, Lin Wenxia, Qin Yuesi, He Ying, Guo Jing, Xiao Min, Chen Mingling
Hospital of Chengdu University of Traditional Chinese Medicine.
Chengdu Integrated TCM & Western Medicine Hospital, Chengdu, Sichuan Province, P. R. China.
Medicine (Baltimore). 2020 Oct 2;99(40):e22586. doi: 10.1097/MD.0000000000022586.
Neurodermatitis is a common inflammatory and allergic disease, characterized by itching and lichenification plaque. Some studies have reported cupping therapy (CT) for the treatment of neurodermatitis. However, the effectiveness and safety are still uncertain. This study aims to evaluate the efficacy and safety of CT for the treatment of patients with neurodermatitis.
We will retrieve the following electronic databases systematically: Pubmed, Web of Science, Embase, the Cochrane Library, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, Chinese Biomedical Literature Database, and Wanfang database from their inception to December 2020. Other literature resources will be manually searched. Published randomized controlled trials (RCTs) and quasi-randomized controlled trials (q-RCTs) on the topic will be retrieved by 2 investigators independently. We will apply a fixed-effect model or random effect model basis on the heterogeneity test and employ with RevMan 5.3 software for data synthesis. The total clinical effective rate will be selected as the primary outcome, skin disease quality of life index score, recurrence rate, and adverse events as secondary outcomes.
This study will comprehensively summarize the high-quality trials to determine the efficacy and safety of CT for the treatment of patients with neurodermatitis.
Our systematic review will present evidence for the efficacy and safety of CT to neurodermatitis patients.
DOI 10.17605/OSF.IO/6DCM3.
神经性皮炎是一种常见的炎症性过敏性疾病，其特征为瘙痒和苔藓样变斑块。一些研究报道了拔罐疗法（CT）用于治疗神经性皮炎。然而，其有效性和安全性仍不确定。本研究旨在评估CT治疗神经性皮炎患者的疗效和安全性。
我们将系统检索以下电子数据库：从创刊至2020年12月的PubMed、科学网、Embase、Cochrane图书馆、中国科学期刊数据库、中国知网数据库、中国生物医学文献数据库和万方数据库。其他文献资源将进行手工检索。两名研究者将独立检索关于该主题已发表的随机对照试验（RCT）和半随机对照试验（q-RCT）。我们将根据异质性检验应用固定效应模型或随机效应模型，并使用RevMan 5.3软件进行数据合成。将总临床有效率作为主要结局，皮肤病生活质量指数评分、复发率和不良事件作为次要结局。
本研究将全面总结高质量试验，以确定CT治疗神经性皮炎患者疗效和安全性。
我们的系统评价将为CT对神经性皮炎患者的疗效和安全性提供证据。
DOI 10.17605/OSF.IO/6DCM3
