用于检测恒河猴及其他非人灵长类动物结核分枝杆菌复合群感染的干扰素-γ检测
Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates.
作者信息
Yee JoAnn L, Prongay Kamm, Miles Brodie, Smedley Jeremy, Hansen Scott G, Axthelm Michael K, Ardeshir Amir, Van Rompay Koen K A, Timmel Gregory, Roberts Jeffrey A
机构信息
California National Primate Research Center, University of California, Davis, California.
Oregon National Primate Research Center, Oregon Health Sciences University, Beaverton, Oregon.
出版信息
J Med Primatol. 2019 Aug;48(4):260-263. doi: 10.1111/jmp.12420. Epub 2019 May 6.
Abstract
We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.
摘要
我们已经设计了一种检测非人灵长类动物结核分枝杆菌复合群感染的检测方法。使用市售试剂引发特定免疫反应，该反应通过γ-干扰素释放来测量。使用来自实验性感染结核分枝杆菌的恒河猴的血样进行的初步评估区分了感染动物和未感染动物。
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