Yee JoAnn L, Prongay Kamm, Miles Brodie, Smedley Jeremy, Hansen Scott G, Axthelm Michael K, Ardeshir Amir, Van Rompay Koen K A, Timmel Gregory, Roberts Jeffrey A
California National Primate Research Center, University of California, Davis, California.
Oregon National Primate Research Center, Oregon Health Sciences University, Beaverton, Oregon.
J Med Primatol. 2019 Aug;48(4):260-263. doi: 10.1111/jmp.12420. Epub 2019 May 6.
We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.
我们已经设计了一种检测非人灵长类动物结核分枝杆菌复合群感染的检测方法。使用市售试剂引发特定免疫反应,该反应通过γ-干扰素释放来测量。使用来自实验性感染结核分枝杆菌的恒河猴的血样进行的初步评估区分了感染动物和未感染动物。