Programa de Pós-Graduação em Neuropsiquiatria e Ciências do Comportamento, Universidade Federal de Pernambuco (UFPE), Recife, Brazil.
CITENC (Centro integrado de tecnologia em neurociência), Centro Integrado de Tecnologia e Pesquisa (CINTEP) - Centro Universitário Osman Lins (FACOL), Vitória de Santo Antão, Brazil.
Synapse. 2019 Aug;73(8):e22103. doi: 10.1002/syn.22103. Epub 2019 May 17.
Environmental enrichment (EE) can be related to changes in the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of adult rodents. Exposure to EE may also induce neurogenesis in the dentate gyrus (DG). The aim of this systematic review was to analyze the current literature on the correlation between neurogenesis and BDNF expression in the hippocampal DG region resulting from exposure to EE, which is associated with changes in memory, in rodents.
Bibliographic searches of the Medline/PubMed and ScienceDirect databases were carried out, and 334 studies were found. A predefined protocol was used and registered on PROSPERO, and 32 studies were included for qualitative synthesis. The PRISMA was used to report this systematic review.
Most of the included studies showed that there is little evidence in the literature demonstrating that memory changes resulting from EE are dependent on BDNF expression and that there is an induction of neurogenesis in the hippocampal DG. However, the observed increase in molecular expression levels and cell proliferation is dependent on the age, the timing and duration of exposure to EE. Regarding the methodological quality of the studies, the majority presented a risk of bias due to the high variability in the age of the animals.
There are few studies in the literature that correlate the molecular and cellular mechanisms involved in neurogenesis in the hippocampal DG with BDNF expression in this region in rodents exposed to EE; however, there are other factors that can modulate this neurogenesis.
环境丰富（EE）可能与成年啮齿动物海马脑源性神经营养因子（BDNF）表达的变化有关。暴露于 EE 也可能诱导齿状回（DG）中的神经发生。本系统评价的目的是分析目前关于 EE 引起的海马 DG 区神经发生和 BDNF 表达与记忆变化相关的文献，这与啮齿动物的记忆变化有关。
对 Medline/PubMed 和 ScienceDirect 数据库进行了文献检索，发现了 334 项研究。使用预定义的方案并在 PROSPERO 上注册，纳入了 32 项研究进行定性综合分析。本系统评价采用 PRISMA 进行报告。
大多数纳入的研究表明，文献中几乎没有证据表明 EE 引起的记忆变化依赖于 BDNF 表达，并且在海马 DG 中诱导了神经发生。然而，观察到的分子表达水平和细胞增殖的增加依赖于年龄、暴露于 EE 的时间和持续时间。关于研究的方法学质量，由于动物年龄的高度变异性，大多数研究都存在偏倚风险。
在文献中，很少有研究将涉及海马 DG 中神经发生的分子和细胞机制与 EE 暴露的啮齿动物该区域中 BDNF 表达相关联；然而，还有其他因素可以调节这种神经发生。
