Liu Yajun, Liu Xiaowei
a Department of Gastroenterology , Xiangya Hospital, Central South University , Changsha , China.
Scand J Gastroenterol. 2019 May;54(5):521-527. doi: 10.1080/00365521.2019.1609077. Epub 2019 May 6.
Inflammatory bowel disease is a chronic nonspecific inflammatory disease of the intestine. Its pathogenesis is not yet fully understood. It may be related to heredity, environmental triggers, infection, immune dysfunction and other factors. Purinergic receptor (P2X7R) ligand-gated ion channel is closely related to inflammation and widely expressed in intestinal cells. Previous studies have shown that ATP/P2X7R signal is involved in the pathogenesis of intestinal inflammation, but its specific mechanism needs further study. This article reviews the research progress of P2X7 receptor in inflammatory bowel disease.
炎症性肠病是一种肠道慢性非特异性炎症性疾病。其发病机制尚未完全明确。它可能与遗传、环境诱因、感染、免疫功能障碍等因素有关。嘌呤能受体（P2X7R）配体门控离子通道与炎症密切相关，在肠道细胞中广泛表达。以往研究表明，ATP/P2X7R信号参与肠道炎症的发病机制，但其具体机制有待进一步研究。本文综述了P2X7受体在炎症性肠病中的研究进展。
