Simonsson B, Nilsson K, Terenius L, Glimelius B
Scand J Haematol. 1978 Nov;21(5):379-89.
Chronic lymphocytic leukaemia (CLL) has a variable clinical course and there is a great need of new prognostic laboratory parameters in this disease. 24 CLL patients were subjected to routine haematological and clinical investigation. The leukaemic cells were analyzed for surface immunoglobulins, complement and sheep red blood cell receptors, Concanavalin A-induced agglutination, cytoplasmic glucocorticoid receptor and for proliferative activity by measurement of tritiated thymidine incorporation. The surface markers studied indicated that all cases were of B-cell origin. Only 5 of 23 patients studied had normal serum immunoglobulin levels. These cases showed a nonprogressive disease. 8 patients had increased infection tendency, all of whom had subnormal IgG levels; 4 of them also had subnormal IgA and IgM and 2 had subnormal IgA levels. 5 out of 6 patients with progressive disease and 3 of 11 with nonprogressive disease had an increased proliferative index, indicating a correlation between this parameter and disease progression. ConA agglutinability was not correlated to disease activity. Cells from 17 of 22 patients showed measurable amounts of glucocorticoid receptor. The 5 patients lacking this receptor had inactive disease.
慢性淋巴细胞白血病（CLL）临床病程多变，对该病新的预后实验室指标有很大需求。对24例CLL患者进行了常规血液学和临床检查。分析白血病细胞的表面免疫球蛋白、补体和绵羊红细胞受体、刀豆球蛋白A诱导的凝集、细胞质糖皮质激素受体，并通过测量氚标记胸腺嘧啶核苷掺入来分析其增殖活性。所研究的表面标志物表明所有病例均起源于B细胞。在23例研究患者中，只有5例血清免疫球蛋白水平正常。这些病例显示疾病呈非进行性。8例患者感染倾向增加，所有患者的IgG水平均低于正常；其中4例患者的IgA和IgM水平也低于正常，2例患者的IgA水平低于正常。6例进展性疾病患者中有5例以及11例非进展性疾病患者中有3例增殖指数升高，表明该参数与疾病进展之间存在相关性。ConA凝集性与疾病活动度无关。22例患者中有17例的细胞显示出可测量的糖皮质激素受体量。缺乏该受体的5例患者疾病无活动。
