Louredo B-V, Vargas P-A, Pérez-de-Oliveira M-E, Lopes M-A, Kowalski L-P, Curado M-P
Department of Oral Diagnosis, Oral Pathology Area Piracicaba Dental School, State University of Campinas (UNICAMP) Av. Limeira, 901, 13.414-903, Piracicaba, São Paulo, Brazil
Med Oral Patol Oral Cir Bucal. 2022 May 1;27(3):e274-e284. doi: 10.4317/medoral.25147.
Lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC) represent a major health problem in the global scenario. In South America, the highest incidence rates are seen in Brazil. Therefore, the epidemiological and clinical profile and survival outcomes of lip, oral cavity, and oropharyngeal SCC was studied in São Paulo State, Brazil.
The clinicopathological data of 12,099 patients with lip, oral cavity, and oropharyngeal SCC were obtained from hospital cancer registries of the Fundação Oncocentro de São Paulo, Brazil (2010-2015). Survival rates and other analyses were performed using SPSS software.
A clear male predominance was observed, particularly for patients with oropharyngeal SCC (88.3%). The average age of patients was higher for lip cases (65 ± 13.5 years) compared to other sites. The schooling level was low for most patients, especially in lip cases (87.9%). Most of the patients with oral cavity (71.8%) and oropharyngeal (86.3%) SCC had advanced-stage (III-IV) disease. However, the majority of lip cases (83.3%) were at an early stage (I-II). Surgical excision was the main treatment for lip (72%) and oral cavity SCC (23.5%), and chemoradiotherapy was the main treatment for oropharyngeal SCC (40.2%). The 5-year overall survival (OS) for patients with lip, oral cavity, and oropharyngeal SCC were 66.3, 30.9, and 22.6%, respectively. Multivariate analysis revealed that the determinants of OS were different for lip, oral cavity, and oropharyngeal SCC, except for those at the clinical stage, which was an independent predictor for all sites.
OS-independent determinants varied according to the affected site. Oral cavity and oropharyngeal SCC presented worse survival rates than those for lip SCC.
唇、口腔和口咽鳞状细胞癌（SCC）是全球范围内的一个主要健康问题。在南美洲，巴西的发病率最高。因此，对巴西圣保罗州唇、口腔和口咽SCC的流行病学和临床特征以及生存结果进行了研究。
从巴西圣保罗肿瘤中心基金会的医院癌症登记处获取了12099例唇、口腔和口咽SCC患者的临床病理数据（2010 - 2015年）。使用SPSS软件进行生存率及其他分析。
观察到明显的男性优势，尤其是口咽SCC患者（88.3%）。与其他部位相比，唇部病例患者的平均年龄更高（65±13.5岁）。大多数患者的受教育程度较低，尤其是唇部病例（87.9%）。大多数口腔（71.8%）和口咽（86.3%）SCC患者患有晚期（III - IV期）疾病。然而，大多数唇部病例（83.3%）处于早期（I - II期）。手术切除是唇部（72%）和口腔SCC（23.5%）的主要治疗方法，而放化疗是口咽SCC的主要治疗方法（40.2%）。唇、口腔和口咽SCC患者的5年总生存率（OS）分别为66.3%、30.9%和22.6%。多因素分析显示，除临床分期是所有部位的独立预测因素外，唇、口腔和口咽SCC的OS决定因素各不相同。
与OS无关的决定因素因受累部位而异。口腔和口咽SCC的生存率低于唇部SCC。
