Allen C A, Hogg N
Cancer Res. 1987 Jun 1;47(11):2919-23.
Forty-eight human colorectal adenocarcinomas, removed at different stages of development, have been examined immunohistochemically for the expression of class II molecules and for the relationship of such class II expression to infiltrating leukocytes. Forty-four% of tumor epithelium samples express class II molecules. This expression is confined to the proteins coded for by the HLA-D/DR subregion although the surrounding infiltrating cells express HLA-D/DR, -DQ, and -DP coded proteins. In addition, there are significantly greater numbers of mononuclear phagocytes and T-cells of the CD8 antibody-positive subset associated with the tumors expressing class II molecules on tumor epithelium compared to the class II-negative tumors. The T-cells appear not to be activated judging by the lack of expression of the receptor for interleukin-2 but the mononuclear phagocytes express CR1, the receptor for the complement component C3b, which suggests that they are stimulated.
对48例处于不同发展阶段切除的人类结肠腺癌进行了免疫组织化学检查，以检测II类分子的表达以及这种II类表达与浸润性白细胞的关系。44%的肿瘤上皮样本表达II类分子。这种表达仅限于由HLA-D/DR亚区编码的蛋白质，尽管周围浸润细胞表达HLA-D/DR、-DQ和-DP编码的蛋白质。此外，与II类阴性肿瘤相比，在肿瘤上皮表达II类分子的肿瘤中，与肿瘤相关的CD8抗体阳性亚群的单核吞噬细胞和T细胞数量明显更多。根据白细胞介素-2受体的表达缺失判断，T细胞似乎未被激活，但单核吞噬细胞表达补体成分C3b的受体CR1，这表明它们受到了刺激。
