Uracz W, Stachura J, Pituch-Noworolska A, Popiela T, Czupryna A, Zembala M
Department of Clinical Immunology, Copernicus School of Medicine, Cracow, Poland.
Cancer Immunol Immunother. 1988;27(2):171-6. doi: 10.1007/BF00200023.
The expression of MHC class II determinants Ia.7 (detected by cross reactive mouse anti-Iak antibody) and HLA-DR on monocytes (MO) of gastric and colorectal cancer patients was examined. An increased proportion of MO bearing the Ia.7 determinant was found, while the number of MO expressing DR was not elevated. In gastric cancer patients the increased expression of the Ia.7 determinant was most pronounced in advanced cancer (stage IVA and IVB). The increased expression of this determinant was related to the presence of the tumour as the number of MO expressing Ia.7 decreased 6 months following surgical resection of the tumour. Further, the increased expression of Ia.7 on MO correlated with the tumour infiltration of the serosa. The Ia.7 determinants were mainly expressed on MO which also expressed the receptor for the Fc part of immunoglobulin. Immunostaining in cellular infiltrates surrounding the tumour revealed that Ia.7+ macrophages (MO) were more numerous than in normal gastric mucosa and severe chronic gastritis and were mostly present in close proximity to tumour cells, while DR+MO were mainly localized within the stromal tissue of the tumour and their number was not increased in cancer infiltrates. These observations indicate that the Ia.7+ subpopulation of MO may be involved in the anti-tumour response of the host.
检测了胃癌和结直肠癌患者单核细胞（MO）上MHC II类决定簇Ia.7（通过交叉反应性小鼠抗Iak抗体检测）和HLA - DR的表达。发现携带Ia.7决定簇的MO比例增加，而表达DR的MO数量未升高。在胃癌患者中，Ia.7决定簇的表达增加在晚期癌症（IVA期和IVB期）最为明显。该决定簇表达的增加与肿瘤的存在相关，因为在肿瘤手术切除6个月后，表达Ia.7的MO数量减少。此外，MO上Ia.7表达的增加与浆膜的肿瘤浸润相关。Ia.7决定簇主要表达于也表达免疫球蛋白Fc部分受体的MO上。肿瘤周围细胞浸润的免疫染色显示，Ia.7 +巨噬细胞（MO）比正常胃黏膜和重度慢性胃炎中更多，且大多紧邻肿瘤细胞，而DR + MO主要定位于肿瘤的间质组织内，其数量在癌浸润中未增加。这些观察结果表明，MO的Ia.7 +亚群可能参与宿主的抗肿瘤反应。
