白细胞介素2对淋巴细胞运动的抑制作用。
Inhibition of lymphocyte motility by interleukin 2.
作者信息
Hoon D S, Wen D R, Stene M, Gupta R K, Cochran A J
出版信息
Clin Exp Immunol. 1986 Dec;66(3):566-73.
These studies described were designed to determine whether interleukin 2 (IL-2) inhibits lymphocyte migration. The human lymphoblastoid cell line QIMR-WIL was used as an indicator of lymphocyte migration inhibition. Interleukin 2 inhibited QIMR-WIL migration in a dose-dependent manner, high doses of IL-2 (100 units) being strongly inhibitory, and low doses (12.5 units) less inhibitory. Purified natural IL-2 and recombinant IL-2 both inhibited QIMR-WIL migration. The effect of IL-2 on lymphocyte migration was specific. When the IL-2 receptors were blocked with anti-Tac (anti-IL-2 receptor) antibodies, the inhibitory effect of IL-2 was significantly reduced. Similarly antibody to IL-2 blocked the inhibitory effect of IL-2. Lymph node lymphocytes were also used as indicator cells in migration studies and IL-2 inhibited their motility. These data suggest a role for IL-2 in inhibiting lymphocyte migration similar to that of lymphocyte migration inhibition factor produced by antigen- or mitogen-stimulated T lymphocytes. While it is widely recognized that lymphocyte motility can be reduced by lymphocyte migration inhibition factor, these data indicate that IL-2 can also reduce lymphocyte motility.
上述所描述的这些研究旨在确定白细胞介素2（IL-2）是否抑制淋巴细胞迁移。人淋巴母细胞系QIMR-WIL被用作淋巴细胞迁移抑制的指标。白细胞介素2以剂量依赖的方式抑制QIMR-WIL迁移，高剂量的IL-2（100单位）具有强烈的抑制作用，而低剂量（12.5单位）的抑制作用较弱。纯化的天然IL-2和重组IL-2均抑制QIMR-WIL迁移。IL-2对淋巴细胞迁移的作用具有特异性。当用抗Tac（抗IL-2受体）抗体阻断IL-2受体时，IL-2的抑制作用显著降低。同样，抗IL-2抗体也阻断了IL-2的抑制作用。在迁移研究中，淋巴结淋巴细胞也被用作指示细胞，IL-2抑制其运动性。这些数据表明IL-2在抑制淋巴细胞迁移中发挥作用，类似于抗原或丝裂原刺激的T淋巴细胞产生的淋巴细胞迁移抑制因子的作用。虽然人们普遍认识到淋巴细胞迁移抑制因子可降低淋巴细胞运动性，但这些数据表明IL-2也可降低淋巴细胞运动性。
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